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Angiotensin Receptor Blockers in Aortic Stenosis — ARBAS  

Aortic Stenosis Clinical Trial

Official title:
Impact of Angiotensin Receptor Blockers in Aortic Stenosis - a Randomized Controlled Trial

Clinical Trial Summary

This study is intended to investigate the effect of angiotensin receptor blockers (ARBs) on mild-to-moderate aortic stenosis.

Clinical Trial Description

Studies support the concept that activation of the renin-angiotensin system may be involved in the progression of valve stenosis and myocardial fibrosis in aortic stenosis. Furthermore recent studies have shown that renin-angiotensin system medication may slow down aortic stenosis progression rate and left ventricle remodeling. Thus the present study is a randomized control trial to test the efficacy of the angiotensin receptor blocker (ARB) to slow down aortic stenosis progression and left ventricular remodeling/dysfunction in patients with mild-to-moderate aortic stenosis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04913870
Study type Interventional
Source Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Contact Marie-Annick Clavel, PhD
Phone 418-656-8711
Email Marie-Annick.Clavel@criucpq.ulaval.ca
Status Recruiting
Phase Phase 4
Start date February 1, 2020
Completion date February 2025
View Details
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