Interest of Pulse Wave Velocity Measurement as a Predictor of Severity of Aortic Stenosis

Aortic Stenosis Clinical Trial

— VOPRABIO  

Official title:

Interest of Pulse Wave Velocity Measurement as a Predictor of Severity of Aortic Stenosis

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT03140735
• Other study ID #: PI2016_843_0035
• Status: Withdrawn
• Phase: N/A
• Start date: July 3, 2017
• Est. completion date: June 20, 2023

Study information

• Verified date: July 2023
• Source: Centre Hospitalier Universitaire, Amiens
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Aortic valve pathology is the third most common cardiovascular disease after coronary artery disease and hypertension, which is responsible for severe morbidity and mortality in elderly patients and requires surgical treatment in its most severe form of progression. The purpose of this study is to find a link between arterial stiffness and degenerative aortic stenosis. If this link is established, arterial stiffness may become a medical therapeutic target in order to delay the evolution of the disease.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: June 20, 2023
• Est. primary completion date: June 20, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients over 18 years of age, without legal protection (guardianship or curatorship),

• Stable hemodynamic status.

• Affiliation to a social security scheme

Exclusion Criteria:

• Hemodynamically unstable patients: Systolic PA <10 cmHg, rapid peripheral pulse and spinning, mottling, obnubilation, oliguria, sweating, coma

• History of significant valvulopathy other than an aortic stenosis,

• Pregnancy.

• Patient under tutelage or curatelle or deprived of public right.

Related Conditions & MeSH terms

• Aortic Stenosis
• Aortic Valve Stenosis
• Constriction, Pathologic
• Pulse Wave

Intervention

Other:
• Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction
Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction
• Control group without heart disease
Control group without heart disease

Locations

Country	Name	City	State
France	CHU Amiens Picardie	Amiens	Picardie

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire, Amiens

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Analysis of echocardiographic measurements of possible differences between average VOP and Sao i in terms of RA severities	Analysis of echocardiographic measurements of possible differences between average VOP and Sao i in terms of RA severities	10 years