Aortic Dissection Clinical Trial
Official title:
Population Pharmacokinetics and Individualized Administration of Lassila Tazobactam in Patients Undergoing CRRT After Aortic Dissection
The individualized drug use research on optimizing piperacillin tazobactam for CRRT of hospital-acquired pulmonary infection after cardiopulmonary bypass is still in the initial stage at home and abroad, lacking systematic research data. With the help of the population pharmacokinetic model, it can help clinicians to formulate individualized drug administration plans for such patients and provide methodological and data support for precise treatment. The rational use of piperacillin tazobactam will play an important role in reducing the use of carbapenems and curbing the occurrence of drug resistance.
The incidence of acute renal failure after aortic dissection can be as high as 30%. In order to reduce mortality, most patients need continuous renal replacement therapy (CRRT). The concentration of antimicrobial drugs in patients receiving CRRT is often lower than the treatment level, which leads to treatment failure. The drug clearance rate of critically ill patients may change every day and it is difficult to estimate, especially when the renal function deteriorates and CRRT begins. As a time-dependent antimicrobial drug, increasing the% t > MIC of piperacillin tazobactam is closely related to ensuring clinical efficacy. However, the molecular weight of piperacillin tazobactam is less than 2000 d, which can easily pass through the filter membrane. All CRRT methods have the same clearance rate. Meanwhile, the binding rate of piperacillin and tazobactam to plasma protein is only about 30%, which is easy to clear through CRRT. As a result, the curative effect of piperacillin tazobactam in treating hospital-acquired pneumonia after aortic dissection is not good according to the conventional dosage and administration. More and more doctors will consider choosing carbapenems as soon as possible, which is related to national health. Therefore, the traditional pharmacokinetic study is no longer applicable, and it can't provide a basis for clinical determination of individualized drug use plan of piperacillin and tazobactam, while the population pharmacokinetic study can effectively solve this problem. The frequency of blood collection from patients is low (usually 2 ~ 4 blood collection points), which is the most advanced method for individualized drug use research in the world at present [10]. Methods The Nonlinear mixed effect Model (non-MEM) was used to calculate the average and variability of pharmacokinetic parameters in patients, and the synergistic effect of patient factors (such as age and weight) on pharmacokinetic parameters could be evaluated, thus providing a reliable basis for formulating individualized and accurate drug administration plan and improving the success rate of anti-infection. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05582967 -
The DAShED (Diagnosis of Aortic Syndrome in the ED) Study
|
||
Terminated |
NCT04116684 -
Digital Home Blood Pressure Monitoring in Type B Aortic Dissection Patients
|
N/A | |
Completed |
NCT02086136 -
Aortic Dissection Detection Risk Score Plus D-dimer in Suspected Acute Aortic Dissection
|
||
Recruiting |
NCT02201589 -
Feasibility of Endovascular Repair Of Ascending Aortic Pathologies
|
N/A | |
Recruiting |
NCT03948555 -
Magnetic Resonance Imaging (MRI) for Aortic Dissection to Visualise Inflammation
|
||
Enrolling by invitation |
NCT05912608 -
Optimal Strategy for Repair of Type A Acute Aortic Dissection
|
||
Recruiting |
NCT03707743 -
Registry of Patients With Acute/Subacute Type B Aortic Dissection Treated by Means of the STABILISE Technique (STABILISE)
|
||
Enrolling by invitation |
NCT00583817 -
Endovascular Treatment of Thoracic Aortic Disease
|
N/A | |
Recruiting |
NCT05073991 -
Incidence of Mortality and Complications After Lung Surgery, Open Thoracic Aortic Repair, TEVAR, EVAR.
|
||
Not yet recruiting |
NCT02523300 -
Glucocorticoid on the Prognosis of TEVAR
|
N/A | |
Completed |
NCT01197651 -
Aortic-Stent-Register
|
N/A | |
Recruiting |
NCT04471909 -
NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness
|
N/A | |
Not yet recruiting |
NCT06044259 -
Study Comparing Hemiarch Replacement and Hemiarch Plus Stent Implantation in Acute Aortic Dissection
|
N/A | |
Completed |
NCT05039814 -
Prediction of Postoperative Acute Kidney Injury in Patients With Acute Type A Aortic Dissection Using Cystatin C
|
||
Recruiting |
NCT03780738 -
A Validation Study of The Relationship Between ALDH2 and Aortic Dissection
|
||
Completed |
NCT03647566 -
18F Sodium Fluoride PET/CT in Acute Aortic Syndrome
|
||
Enrolling by invitation |
NCT05800743 -
Evaluation of the GORE® Ascending Stent Graft
|
N/A | |
Recruiting |
NCT03347812 -
Clinical Study for Evaluating the Safety and Efficacy of Total Endovascular Aortic Arch Repair
|
N/A | |
Completed |
NCT05044494 -
Surgery for Delay-recognized or Defer-operated Type A Aortic Dissection
|
||
Terminated |
NCT02958098 -
My Research Legacy Pilot Study
|