Study on Susceptibility Genes and Pathogenic Mechanism of Non-syndromic Familial Aortic Dissection

Aortic Dissection Clinical Trial

Official title:

Study on Susceptibility Genes and Pathogenic Mechanism of Non-syndromic Familial Aortic Dissection

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04439565
• Other study ID #: https://orcid.org/0000-0002-05
• Status: Recruiting
• Start date: June 17, 2020
• Est. completion date: July 17, 2023

Study information

• Verified date: June 2020
• Source: Chinese Medical Association
• Contact: Jing Zaiping, professor
• Phone: 02131161670
• Email: xueguanky[@]163.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Aortic dissection is dangerous and difficult to predict, so it is particularly important to carry out early prevention, diagnosis and rational treatment for high-risk groups. The related genes found in previous studies can not be detected in all patients with dissection; at present, the pathogenesis of non-syndromic aortic dissection is not clear, of which about 20% of patients have family aggregation and have the general representative characteristics of non-syndromic dissection. In this project, the peripheral blood samples of core family subjects were detected by sequencing technique. analyze disease-related susceptibility genes; 2 determine the effect of susceptibility genes on the incidence of dissection in mice through animal experiments; and 3 explore the effect of susceptibility genes on cell function at the cellular level.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: July 17, 2023
• Est. primary completion date: June 17, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Family inclusion criteria: 1 at least one person in each generation of a family has aortic dissection, and at least two generations of members can be included;

Exclusion Criteria:

• Pedigree exclusion criteria: pedigree members have marfan syndrome, Loeys-Dietz syndrome, Ehler-Danlos syndrome, aneurysm-Osteoarthritis syndrome and other syndroms

Related Conditions & MeSH terms

• Aneurysm
• Aneurysm, Dissecting
• Aortic Aneurysm
• Aortic Dissection
• Aortic Dissection, Familial, With or Without Aortic Aneurysm
• Disease Susceptibility
• Family Research

Intervention

Genetic:
• movement
aortic dissection or aneurysm patients this is an observation cohort study about a Non-syndromic Familial Aortic Dissection without intervention.

Locations

Country	Name	City	State
China	Changhaihospital	Shanghai	Shanghai

Sponsors (1)

Lead Sponsor	Collaborator
Chinese Medical Association

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	gege	Discovery of known or unknown genes	2023