LANDMARC Study: a Study With Focus on Aorta Ascendens

Status Not yet recruiting

Clinical Trial Summary

Rationale: Aortic diameter is currently used as a gold standard in international guidelines for prediction of aorta pathology (aortic aneurysm and aortic dissection). However, aortic diameter has proven to be insufficiently accurate for making decisions about well-timed preventive interventions. The LANDMARC study will take place in line with the FIBAA-bank ('Correlatie tussen cardiovasculaire FIBroseringsgraad en Aorta elongatie, dilatatie en Atria dilatatie (FIBAA-bank): een biobank & databank onderzoek met focus op aorta en atria' (METC-number 2022-3164)), and aims to reveal the undiscovered relationship between WSS (wall shear stress) values and aortic strain. In combination with data from the FIBAA-bank, the LANDMARC study will provide more accurate information for future risk stratification models for cardiovascular pathology (with focus on aortic disease). Objectives: Primary objective: indication of the association between WSS (peak WSS and WSS gradient) (through 4D-flow MR and CT) and aortic strain. Secondary objective: indication of the association between (hemo)dynamic processes within the body (aortic elongation/aortic strain) and (patho-)physiological changes (degree of cardiovascular tissue fibrosis).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05655767
Study type	Observational
Source	Maastricht University Medical Center
Contact	Sophie ML van de Walle, PhD student
Phone	+31643904530
Email	sophie.vande.walle@mumc.nl
Status	Not yet recruiting
Phase
Start date	December 15, 2022
Completion date	January 15, 2025

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04149600` - Identification of Genetic Causes of Calcific Aortic Valve Disease
Enrolling by invitation	`NCT04035356` - HAART Annuloplasty Device Valve Repair Registry
Recruiting	`NCT02729064` - Intraoperative Nasal Insulin Effect on Plasma and CSF Insulin Concentration and Blood Glucose	Phase 1
Completed	`NCT02467062` - Implementation of Non-size Markers Derived From 4D Flow MRI of Patients With Aortic Disease.	N/A
Completed	`NCT02283307` - Dual Energy CT Urography With Reduced Iodinated Contrast	N/A
Completed	`NCT01678261` - X-chromosome Inactivation, Epigenetics and the Transcriptome	N/A
Terminated	`NCT01055275` - Cook Iliac Branch Graft Post-market Registry	N/A
Completed	`NCT00615888` - Fast Track Management in Elective Open Infrarenal Aortic Aneurysm Repair	N/A
Completed	`NCT03510793` - Microcirculation and Anesthesia in Vascular Surgery
Completed	`NCT03207568` - RE-GENERATION: The Safety and Performance of the Relay Pro and Relay NBS Pro Stent-graft Devices in the European Union (EU)	N/A
Recruiting	`NCT05073991` - Incidence of Mortality and Complications After Lung Surgery, Open Thoracic Aortic Repair, TEVAR, EVAR.
Not yet recruiting	`NCT01918969` - Reference Values of Circulating Endothelial Progenitor Cells	N/A
Not yet recruiting	`NCT01918982` - Circulating Endothelial Progenitor Cells and Aortic Aneurysm	N/A
Completed	`NCT02000544` - Clinical Evaluation of a Modular Extracorporeal Circulation Circuit	N/A
Completed	`NCT01256372` - An Trial of Two Dosing Regimens of AP214 for the Prevention of Kidney Injury in Patients Undergoing Cardiac Surgery	Phase 2
Recruiting	`NCT00661518` - PET/CT Imaging of Aneurysm Wall Inflammation	N/A
Completed	`NCT00094575` - Standard Open Surgery Versus Endovascular Repair of Abdominal Aortic Aneurysm (AAA)	Phase 4
Recruiting	`NCT04471909` - NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness	N/A
Recruiting	`NCT05603520` - Phenotyping Heterogeneity and Regionality of the Aorta
Completed	`NCT03727542` - Influence of Short AV Delay Permanent Pacing on Matrix Metalloproteinase Levels	N/A