Anxiety Clinical Trial
Official title:
Effect of Different Doses of Dexmedetomidine on Cerebral Oxygen Saturation and Postoperative Anxiety in Elderly Patients
To investigate the effect of different doses of dexmedetomidine on Cerebral Oxygen Saturation and Postoperative anxiety in elderly patients undergoing laparoscopic surgery
Status | Recruiting |
Enrollment | 105 |
Est. completion date | March 22, 2023 |
Est. primary completion date | March 22, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 65 Years to 90 Years |
Eligibility | Inclusion Criteria: - Patients aged 65 years or older who underwent elective laparoscopic surgery under general anesthesia - BMI less than 30 kg/m2 - American Society of Anesthesiologists (ASA) grades I-III - The score of Mini Mental state examination=24 Exclusion Criteria: - Patients with heart, lung and other vital organ disorders - The score of Mini Mental state examination=23 - Preoperative psychiatric disorders or long-term use of drugs affecting the psychiatric system - Have severe visual, hearing, speech impairment or other inability to communicate with the visitor - Refuse to sign informed consent - known preoperative left ventricular ejection fraction less than 30%, sick sinus syndrome, severe sinus bradycardia (<50 beats per min [bpm]), or second-degree or greater atrioventricular block without pacemaker |
Country | Name | City | State |
---|---|---|---|
China | The First hosptial of Qinhuangdao | Qinhuangdao | Hebei |
Lead Sponsor | Collaborator |
---|---|
The First Hospital of Qinhuangdao |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Incidence of anxiety at one day after surgery | The three groups of patients were scored on the Self-rating Anxiety Scale on the first day after surgery, and if the Self-rating Anxiety Scale score was = 50 points, the patients developed anxiety, and whether the incidence of anxiety on the first day after surgery in the three groups was statistically significant. | One day after surgery | |
Primary | Incidence of anxiety at three days after surgery | The three groups of patients were scored on the Self-rating Anxiety Scale on the third day after surgery, and if the Self-rating Anxiety Scale score was = 50 points, the patients developed anxiety, and whether the incidence of anxiety on the third day after surgery in the three groups was statistically significant. | Three days after surgery | |
Secondary | Anesthetic drug | The dosage of remifentanil and propofol in different groups were recorded. | Time Frame: during the surgery | |
Secondary | The change of SBP | The change of Systolic blood pressure (SBP) among the three groups. | before anesthesia induction, at the time of intubation, at the beginning of surgery, immediately after surgery , and five minutes after extubation | |
Secondary | The change of rScO2 | The change of regional cerebral oxygen saturation(rScO2) among the three groups. | during the surgery |
Status | Clinical Trial | Phase | |
---|---|---|---|
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