Anxiety Clinical Trial
Official title:
Effects of Duloxetine on Pathological Worry in Patients With Generalized Anxiety Disorder: A fMRI Study
(1) to compare the differences of neural activation of pathological worry between pre-treatment GAD patients and normal subjects; (2) to measure the differences of brain activation on worry in GAD patients before and after duloxetine treatment
The study will recruit 20 GAD patients and 20 healthy controls. Both patients and controls
receive a medical and psychiatric screening procedure at visit 1 and are asked to complete
three self-rating questionnaires and one health questionnaire at visit 1. All qualified
participants will receive functional magnetic resonance imaging (fMRI) at baseline.
The patients will begin treatment with duloxetine 30 mg/day at visit 2 and will be titrated
to 60 mg/day at visit 3 (2 week since drug dispensed). The dosage will be maintained on 60
mg/day for 6 more weeks. During the period, the patients will receive periodic evaluations
at visit 2 (0 week drug dispensed), 3 (2 week since drug dispensed), 4 (4 weeks since drug
dispensed), and 5 (8 weeks since drug dispensed). The patients will receive fMRI examination
at baseline and at the end of the 8-week treatment.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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