Anxiety Disorders Clinical Trial
Official title:
Improving the Control of Fear: Healthy Adults to Pathological Anxiety
The purpose of this study is to use functional magnetic resonance imaging to investigate how
the human brain learns to form associations between neutral and emotional stimuli. The study
is based on the basic principles of Pavlovian conditioning.
When someone learns that a neutral stimulus (such as the sound of a bell) predicts an
unpleasant stimulus (such as a mild electrical shock), the neutral stimulus takes on the
properties of an emotional stimulus.
The investigators are interested in the neural processes involved in this learning in people
with a clinical anxiety disorder and posttraumatic stress disorder (PTSD).
Status | Recruiting |
Enrollment | 40 |
Est. completion date | June 2020 |
Est. primary completion date | June 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 50 Years |
Eligibility |
Inclusion Criteria: 1. Male or female volunteer aged 18-50 years old 2. Able to understand procedures and agree to participate in the study by giving written informed consent. 3. Speaks fluent English. 4. Not taking illicit drugs. 5. No history of neurological problems. 6. Eligible for MRI, including no metal in the body or body piercings that cannot be removed. Exclusion Criteria: 1. Current comorbid Axis 1 psychiatric disorder 2. Women who are current pregnant or breastfeeding 3. Lifetime diagnosis of any psychotic disorder, cognitive suicidal ideation, substance abuse or alcohol dependence, hoarding. 4. Medications that act on the central nervous system that interfere with interpretation of the findings (e.g., painkillers, Adderall) 5. Claustrophobia 6. Patients who are unable to comply with procedures or assessments. |
Country | Name | City | State |
---|---|---|---|
United States | The University of Texas at Austin | Austin | Texas |
Lead Sponsor | Collaborator |
---|---|
University of Texas at Austin |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Changes in functional magnetic resonance imaging (fMRI)-BOLD (blood-oxygen-level dependent) signal in sensory, prefrontal, and limbic regions during a study on the neurobiology of Pavlovian fear conditioning in humans | We are measuring increases in the BOLD signal in response to visual stimuli during a Pavlovian conditioning task in humans. | Only on the day of the experiment | |
Secondary | Skin conductance responses evoked during a Pavlovian fear conditioning task in humans as an index of physiological arousal. | Electrodermal activity collected from the hand that measures increases in sweating, taken as an indicator of Pavlovian fear conditioning | Only on the day of the experiment |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03535805 -
Transdiagnostic, Cognitive and Behavioral Intervention for in School-aged Children With Emotional and Behavioral Disturbances
|
N/A | |
Active, not recruiting |
NCT05006976 -
A Naturalistic Trial of Nudging Clinicians in the Norwegian Sickness Absence Clinic. The NSAC Nudge Study
|
N/A | |
Recruiting |
NCT05419934 -
EMDR Therapy in Young Children, a Double-blinded Randomized Controlled Trial
|
N/A | |
Active, not recruiting |
NCT04136054 -
Better Sleep in Psychiatric Care - Anxiety and Affective Disorders
|
N/A | |
Completed |
NCT04091139 -
Research of Unified Protocol for the Treatment of Common Mental Disorders in Adolescents in Hong Kong
|
Phase 2/Phase 3 | |
Completed |
NCT04647318 -
Physiological Response to Self-compassion Versus Relaxation
|
N/A | |
Active, not recruiting |
NCT05114824 -
Acceptability and Feasibility of an 8-week Online Mindfulness-Based Cognitive Therapy Program Among Undergraduate Students
|
N/A | |
Recruiting |
NCT05843695 -
Enhancing Psychotherapy for Veterans and Service Members With PTSD and Anxiety
|
N/A | |
Completed |
NCT05078450 -
Mood Lifters Online for Graduate Students and Young Professionals
|
N/A | |
Not yet recruiting |
NCT06162624 -
Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons
|
N/A | |
Not yet recruiting |
NCT05863637 -
Intensive Short-Term Dynamic Psychotherapy (ISTDP) for Anxiety Diagnoses in a Primary Care Setting
|
N/A | |
Not yet recruiting |
NCT05747131 -
Emotion Detectives In-Out: Feasibility and Efficacy of a Blended Version of the Unified Protocol for Children
|
N/A | |
Not yet recruiting |
NCT05225701 -
Efficacy of a Transdiagnostic Guided Internet-Delivered Intervention for Emotional, Trauma and Stress-Related Disorders.
|
N/A | |
Completed |
NCT02579915 -
Developing a Low-Intensity Primary Care Intervention for Anxiety Disorders (AIM-PC)
|
N/A | |
Recruiting |
NCT02376959 -
Effect of Spiritist "Passe" Energy Therapy in Reducing Anxiety in Volunteers
|
N/A | |
Recruiting |
NCT02186366 -
Efficacy Study of Abdominal Massage Therapy to Treat Generalized Anxiety Disorder of Deficiency of Both Heart and Spleen Type
|
N/A | |
Not yet recruiting |
NCT02126787 -
Short-term, Intensive Psychodynamic Group Therapy Versus Cognitive-behavioral Group Therapy in the Day Treatment
|
N/A | |
Completed |
NCT02134730 -
School-based Universal Prevention for Anxiety and Depression in Sweden: A Cluster-randomized Trial
|
N/A | |
Withdrawn |
NCT01953042 -
Benefits of a Psychoeducation Program for Those Awaiting Treatment for OCD and OCD Spectrum Disorders
|
N/A | |
Completed |
NCT01333098 -
Antiglucocorticoid Therapy for Cognitive Impairment in Late-life Anxiety Disorders
|
Phase 1/Phase 2 |