Anxiety Disorders Clinical Trial
Official title:
Improving the Control of Fear: Healthy Adults to Pathological Anxiety
The purpose of this study is to use functional magnetic resonance imaging to investigate how
the human brain learns to form associations between neutral and emotional stimuli. The study
is based on the basic principles of Pavlovian conditioning.
When someone learns that a neutral stimulus (such as the sound of a bell) predicts an
unpleasant stimulus (such as a mild electrical shock), the neutral stimulus takes on the
properties of an emotional stimulus.
The investigators are interested in the neural processes involved in this learning in people
with a clinical anxiety disorder and posttraumatic stress disorder (PTSD).
Status | Recruiting |
Enrollment | 40 |
Est. completion date | June 2020 |
Est. primary completion date | June 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 50 Years |
Eligibility |
Inclusion Criteria: 1. Male or female volunteer aged 18-50 years old 2. Able to understand procedures and agree to participate in the study by giving written informed consent. 3. Speaks fluent English. 4. Not taking illicit drugs. 5. No history of neurological problems. 6. Eligible for MRI, including no metal in the body or body piercings that cannot be removed. Exclusion Criteria: 1. Current comorbid Axis 1 psychiatric disorder 2. Women who are current pregnant or breastfeeding 3. Lifetime diagnosis of any psychotic disorder, cognitive suicidal ideation, substance abuse or alcohol dependence, hoarding. 4. Medications that act on the central nervous system that interfere with interpretation of the findings (e.g., painkillers, Adderall) 5. Claustrophobia 6. Patients who are unable to comply with procedures or assessments. |
Country | Name | City | State |
---|---|---|---|
United States | The University of Texas at Austin | Austin | Texas |
Lead Sponsor | Collaborator |
---|---|
University of Texas at Austin |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Changes in functional magnetic resonance imaging (fMRI)-BOLD (blood-oxygen-level dependent) signal in sensory, prefrontal, and limbic regions during a study on the neurobiology of Pavlovian fear conditioning in humans | We are measuring increases in the BOLD signal in response to visual stimuli during a Pavlovian conditioning task in humans. | Only on the day of the experiment | |
Secondary | Skin conductance responses evoked during a Pavlovian fear conditioning task in humans as an index of physiological arousal. | Electrodermal activity collected from the hand that measures increases in sweating, taken as an indicator of Pavlovian fear conditioning | Only on the day of the experiment |
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