Study Of Generalized Anxiety Disorder

Status Completed

Clinical Trial Summary

This study is designed to evaluate the efficacy and safety in Generalized Anxiety Disorder patients

Clinical Trial Description

This study was a multi-center, randomized, placebo-controlled, double-blinded (placebo run-in will be single-blinded), group comparison study.

Paroxetine 20mg/day (achieved via the starting dose of 10 mg/day for the first week) once daily, or placebo was orally administered once daily for 8 weeks (fixed dose was adopted in the Treatment phase) in patients with GAD.

For subjects who were classed as non-responders at Week 8, paroxetine at 30 to 40mg/day (once daily) or placebo (once daily) was orally administered with flexible titration regimen for 4 weeks (fixed dose was adopted in the Treatment phase). The subjects underwent a taper phase in case they received Paroxetine 40mg/day, paroxetine 30mg/day or placebo at treatment completion or study withdrawal. A follow-up examination was conducted after 1 to 5 weeks from the last dose of the investigational product.

The overall study duration requiring subject participation was 10 to 20 weeks. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00135525
Study type	Interventional
Source	GlaxoSmithKline
Contact
Status	Completed
Phase	Phase 2
Start date	May 2003
Completion date	May 2006

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03535805` - Transdiagnostic, Cognitive and Behavioral Intervention for in School-aged Children With Emotional and Behavioral Disturbances	N/A
Active, not recruiting	`NCT05006976` - A Naturalistic Trial of Nudging Clinicians in the Norwegian Sickness Absence Clinic. The NSAC Nudge Study	N/A
Recruiting	`NCT05419934` - EMDR Therapy in Young Children, a Double-blinded Randomized Controlled Trial	N/A
Active, not recruiting	`NCT04136054` - Better Sleep in Psychiatric Care - Anxiety and Affective Disorders	N/A
Completed	`NCT04091139` - Research of Unified Protocol for the Treatment of Common Mental Disorders in Adolescents in Hong Kong	Phase 2/Phase 3
Completed	`NCT04647318` - Physiological Response to Self-compassion Versus Relaxation	N/A
Active, not recruiting	`NCT05114824` - Acceptability and Feasibility of an 8-week Online Mindfulness-Based Cognitive Therapy Program Among Undergraduate Students	N/A
Recruiting	`NCT05843695` - Enhancing Psychotherapy for Veterans and Service Members With PTSD and Anxiety	N/A
Completed	`NCT05078450` - Mood Lifters Online for Graduate Students and Young Professionals	N/A
Not yet recruiting	`NCT06162624` - Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons	N/A
Not yet recruiting	`NCT05863637` - Intensive Short-Term Dynamic Psychotherapy (ISTDP) for Anxiety Diagnoses in a Primary Care Setting	N/A
Not yet recruiting	`NCT05747131` - Emotion Detectives In-Out: Feasibility and Efficacy of a Blended Version of the Unified Protocol for Children	N/A
Not yet recruiting	`NCT05225701` - Efficacy of a Transdiagnostic Guided Internet-Delivered Intervention for Emotional, Trauma and Stress-Related Disorders.	N/A
Completed	`NCT02579915` - Developing a Low-Intensity Primary Care Intervention for Anxiety Disorders (AIM-PC)	N/A
Recruiting	`NCT02186366` - Efficacy Study of Abdominal Massage Therapy to Treat Generalized Anxiety Disorder of Deficiency of Both Heart and Spleen Type	N/A
Recruiting	`NCT02376959` - Effect of Spiritist "Passe" Energy Therapy in Reducing Anxiety in Volunteers	N/A
Not yet recruiting	`NCT02126787` - Short-term, Intensive Psychodynamic Group Therapy Versus Cognitive-behavioral Group Therapy in the Day Treatment	N/A
Withdrawn	`NCT01953042` - Benefits of a Psychoeducation Program for Those Awaiting Treatment for OCD and OCD Spectrum Disorders	N/A
Completed	`NCT02134730` - School-based Universal Prevention for Anxiety and Depression in Sweden: A Cluster-randomized Trial	N/A
Completed	`NCT01333098` - Antiglucocorticoid Therapy for Cognitive Impairment in Late-life Anxiety Disorders	Phase 1/Phase 2