A Study of Hydroxychloroquine Sulfate in the Treatment of Recurrent Spontaneous Abortion With Antiphospholipid Syndrome

Antiphospholipid Syndrome Clinical Trial

Official title:

A Multicenter, Double-blind, Randomized and Parallel Controlled Study of Hydroxychloroquine Sulfate in the Treatment of Recurrent Miscarriage With Antiphospholipid Syndrome

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04624269
• Other study ID #: ShanghaiFMIH-HCQ
• Status: Not yet recruiting
• Phase: Phase 4
• Start date: December 1, 2020
• Est. completion date: February 1, 2023

Study information

• Verified date: November 2020
• Source: Shanghai First Maternity and Infant Hospital
• Contact: Du mengyang, Master
• Phone: 0086-13636467524
• Email: dumengyanga[@]51mch.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The efficacy of low-dose aspirin combined with low-molecular-weight heparin treatment for improving antiphospholipid syndrome and maternal-fetal outcome of patients is recognized by various countries and recommended by the guidelines. However, there are still 20-30% of APS patients whose treatment fails. Therefore, the standard treatment effect is still not ideal, and other treatment options need to be explored. The purpose of this study is to conduct a randomized double-blind, parallel controlled study of patients with recurrent miscarriage and APS in addition to standard treatment, plus hydroxychloroquine sulfate (HCQ) or placebo, to observe the effects of HCQ on pregnancy outcome in patients with abortion and APS, to evaluate the effectiveness and safety of HCQ treatment.

Description:

This study uses a multi-center, double-blind, randomized, parallel-controlled research model. In addition to the standard anticoagulant drugs for antiphospholipid syndrome, patients with recurrent miscarriage and APS who meet the enrollment criteria will be randomly divided into hydroxychloroquine sulfate( HCQ) group or placebo group, and randomly assigned according to a 1:1 ratio. Observe the efficacy and safety.

The Hydroxychloroquine sulfate(HCQ) group is the test group. Hydroxychloroquine sulfate 0.2g/d (sig: 0.1g bid po) will be applied 3 months before pregnancy, pregnancy will be started at the 4th month, and aspirin 50mg/d will be added after menstruation( sig: 25mg bid po), low molecular weight heparin 4000-6000 U/d after ovulation or 1 week before embryo transplantation; the placebo group is the control group, and placebo 0.2g/d (sig: 0.1 g bid po) from the fourth month of pregnancy, add aspirin 50mg/d (sig: 25mg bid po) after menstruation, and add low molecular heparin 4000-6000 U/d after ovulation or 1 week before embryo transplantation Both groups were followed up by telephone every 1 month to obtain medication compliance, whether there were adverse reactions, etc., and both oth groups were followed up every 3 months for non-pregnant women by outpatient service , until pregnancy. If the patient is not pregnant within one year, The clinical study of this patient will be terminated, and the patients will be followed up for adverse reactions by telephone one month and three months after withdrawal. If you are pregnant, follow up in the first trimester immediately, and arrange a follow-up every three months thereafter (defined as follow-up in the first trimester, follow-up in the second trimester and follow-up in the third trimester). The drug was discontinued on the day of delivery and the postpartum follow-up was completed 6 weeks after delivery. So, therefore, the entire study time is approximately 27 months.

The researcher mainly records the subjects' vital signs, laboratory indicators, adverse events and combined medications, as well as related indicators of pregnancy check-ups (such as uterine artery blood flow, presence or absence of pregnancy complications, fetal complications, etc.)

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 384
• Est. completion date: February 1, 2023
• Est. primary completion date: November 1, 2021
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Patients who want to conceive,with recurrent miscarriage and antiphospholipid syndrome (APS) .

• Agree to join the study and sign the informed consent of the study.

Exclusion Criteria:

• Women who are already pregnant.

• Allergies or adverse events to Hydroxychloroquine(HCQ),such as allergies to the active substance -aminoquinoline or allergies to HCQ or any other chemical components of placebo.

• Patients with any changes in the retina or visual field caused by treatment with 4-aminoquinoline compounds;

• HCQ is currently being used

• Weight <45kg

• Psoriasis

• Uncontrolled epilepsy

• Anti-ENA antibody positive

• Renal replacement therapy

• Other serious active complications (human immunodeficiency virus, hepatitis B)

• Porphyria

• History of retinopathy

• History of galactose intolerance, history of lactase deficiency, or history of glucose-galactose malabsorption

• Participate in any other clinical trial drug research at the same time.

• Previous treatment failure with Hydroxychloroquin

• Others: such as poor compliance, or those who cannot be followed up on schedule due to certain factors.

Related Conditions & MeSH terms

• Abortion, Habitual
• Abortion, Spontaneous
• Antiphospholipid Syndrome
• Recurrent Miscarriage
• Syndrome

Intervention

Drug:
• Hydroxychloroquine Sulfate Tablets
Hydroxychloroquine Sulfate Tablets ,0.1mg,bid po

Locations

Country	Name	City	State
China	shanghai First Maternity and Infant Hospital, Tongji University School of Medicin	Shanghai

Sponsors (6)

Lead Sponsor	Collaborator
Shanghai First Maternity and Infant Hospital	Fudan University, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Zhejiang Provincial People's Hospital, Zhejiang Provincial Tongde Hospital

Country where clinical trial is conducted

China, 

References & Publications (6)

Abarientos C, Sperber K, Shapiro DL, Aronow WS, Chao CP, Ash JY. Hydroxychloroquine in systemic lupus erythematosus and rheumatoid arthritis and its safety in pregnancy. Expert Opin Drug Saf. 2011 Sep;10(5):705-14. doi: 10.1517/14740338.2011.566555. Epub — View Citation

Branch DW, Peaceman AM, Druzin M, Silver RK, El-Sayed Y, Silver RM, Esplin MS, Spinnato J, Harger J. A multicenter, placebo-controlled pilot study of intravenous immune globulin treatment of antiphospholipid syndrome during pregnancy. The Pregnancy Loss S — View Citation

Mak A, Cheung MW, Cheak AA, Ho RC. Combination of heparin and aspirin is superior to aspirin alone in enhancing live births in patients with recurrent pregnancy loss and positive anti-phospholipid antibodies: a meta-analysis of randomized controlled trials and meta-regression. Rheumatology (Oxford). 2010 Feb;49(2):281-8. doi: 10.1093/rheumatology/kep373. Epub 2009 Dec 4. Review. — View Citation

Mekinian A, Lazzaroni MG, Kuzenko A, Alijotas-Reig J, Ruffatti A, Levy P, Canti V, Bremme K, Bezanahary H, Bertero T, Dhote R, Maurier F, Andreoli L, Benbara A, Tigazin A, Carbillon L, Nicaise-Roland P, Tincani A, Fain O; SNFMI and the European Forum on A — View Citation

Sciascia S, Branch DW, Levy RA, Middeldorp S, Pavord S, Roccatello D, Ruiz-Irastorza G, Tincani A, Khamashta M, Schreiber K, Hunt BJ. The efficacy of hydroxychloroquine in altering pregnancy outcome in women with antiphospholipid antibodies. Evidence and — View Citation

Sciascia S, Hunt BJ, Talavera-Garcia E, Lliso G, Khamashta MA, Cuadrado MJ. The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies. Am J Obstet Gynecol. 2016 Feb;214(2):273.e1-273.e8. doi: 10.1016/j.ajog. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Hydroxychloroquine can improve the pregnancy outcome of patients with recurrent miscarriage and antiphospholipid syndrome	Hydroxychloroquine is associated with successful pregnancy outcome at 12 weeks of gestation	16 weeks
Secondary	Hydroxychloroquine can reduce the occurrence of complications during pregnancy	Reduced incidence of major adverse pregnancy outcomes related to antiphospholipid syndrome	27 weeks