Antiphospholipid Syndrome Clinical Trial
Official title:
The Prognostic Value of PGF and sFlt1 Variations Induced by the First Low-molecular-weight-heparin Injections in Women With Obstetrical Antiphospholipids Antibody Syndrome Starting a New Pregnancy and Following Treatment in Accordance With International Recommendations
The primary objective of this study is to evaluate plasmatic concentrations of free PGF and
sFlt1 for blood samples taken before a first low-molecular-weight-heparin injection and also
for blood samples taken on the 4th day of injections (the latter correspond to the first
systematic control of platelet counts) in women who have an obstetric antiphospholipid
antibody syndrome and who are initiating a new pregnancy with recommended treatment. Our
goal is to test the prognostic value of these data on the occurrence of:
- pregnancy loss categorized as embryonic loss (before 10 weeks gestation), fetal death
(before 20 weeks gestation), stillbirths (from 20 weeks gestation to delivery), and
neonatal death defined before reaching 28 days of age.
- ischemic placental pathology (pre-eclampsia, retro-placental hematoma, birth of a
small-for-gestational-age infant)
n/a
Observational Model: Cohort, Time Perspective: Prospective
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