Clinical Trials Logo
  1. Home
  2. Antiphospholipid Syndrome
  3. NCT00278616

Hematopoietic Stem Cell Transplantation in Patients With Antiphospholipid Syndrome

ANTIPHOSPHOLIPID SYNDROME Clinical Trial

Official title:
High Dose Cyclophosphamide & CAMPATH-1H With Hematopoietic Stem Cell Transplantation in Patients With Refractory Antiphospholipid Syndrome (APS): A Phase I Trial

Clinical Trial Summary

Antiphospholipid syndrome is disease believed to be due to immune cells, cells which normally protect the body, but are now producing the protein which leads to abnormal clotting in the body. This study is designed to examine whether treating patients with high dose cyclophosphamide together with CAMPATH (drugs which reduce the function of the immune system), followed by return of the previously collected stem cells will result in improvement in the disease. Stem cells are undeveloped cells that have the capacity to grow into mature blood cells, which normally circulate in the blood stream. The purpose of the intense chemotherapy is to destroy the cells in the immune system which may be causing the disease. The purpose of the stem cell infusion is to produce a normal immune system that will no longer attack the body. The study purpose is to examine whether this treatment will result in improvement in the disease. The drugs used in this study treatment are drugs for commonly used for immune suppression.

Clinical Trial Description

n/a

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00278616
Study type Interventional
Source Northwestern University
Contact
Status Withdrawn
Phase Phase 1
Start date August 2005
Completion date October 2011
View Details
See also
  Status Clinical Trial Phase
Completed NCT01475149 - Effect of HCQ on AnxA5 Resistance Assay in Antiphospholipid (aPL) Positive Patients With and Without Systemic Lupus Erythematosus (SLE) N/A
Completed NCT00537290 - A Pilot Study of Rituximab for the Anticoagulation Resistant Manifestations of Antiphospholipid Syndrome Phase 2
Recruiting NCT00616317 - Register for Pediatric Patients With Antiphospholipid Syndrome (APS): European Project Extended Internationally Study
Recruiting NCT00198068 - Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS)
Completed NCT00180817 - Longitudinal Study of the Clinical and Haematological Cause of Women With Antiphospholipid Antibodies.
Completed NCT03682419 - Evaluation of Precision and Accuracy of INR Measurements in a Point of Care Device (OPTIMAL) N/A
Not yet recruiting NCT03303508 - Measurement of Anti-dsDNA by Both CLIFT & ELISA N/A
Recruiting NCT04262492 - International Registry of Thrombotic APS Patients Treated With Direct Oral Anticoagulants
Withdrawn NCT00180778 - Steroids and Antiphospholipid Syndrome- Related Pregnancy Loss Phase 1/Phase 2
Enrolling by invitation NCT05583305 - Prevalence and Etiologies of Intracranial Stenosis in Patients With Antiphospholipid Syndrome
Recruiting NCT05644210 - Telitacicept Followed With Rituximab Therapy on APS Secondary to SLE
Recruiting NCT02303171 - Use of Warfarin After the First Trimester in Pregnant Women With APS Phase 4
Not yet recruiting NCT06420154 - The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refractory Autoimmune Diseases Early Phase 1
Completed NCT00674297 - Effects of Fluvastatin on Proinflammatory and Prothrombotic Markers in Antiphospholipid Syndrome Patients Phase 2
Recruiting NCT05859997 - Universal CAR-T Cells (BRL-301) in Relapse or Refractory Autoimmune Diseases N/A
Recruiting NCT06373003 - Negative Antiphospholipid Syndrome: a Multicentric Study
Recruiting NCT06373926 - Evaluation of Cell Membrane Expression of Annexin A2 on Monocytes by Flow Cytometry in Primary Antiphospholipid Syndrome N/A
Recruiting NCT01818505 - The Influence of Antiphospholipid Antibodies on the Relationship Between Hyperurecemia, Gout and Metabolic Syndrome N/A
Completed NCT00878137 - Reliability of Point-of-care INR Measurements in Patients With Antiphospholipid-antibody Syndrome Treated With Warfarin N/A
Completed NCT01104337 - Drug Interaction Between Paracetamol and Warfarin Phase 4