Antineoplastic Drugs Contamination Prevalence Clinical Trial
Official title:
Assessment of Nurses Internal Contamination by Antineoplastic Drugs in Hospital Centers.
CACIES is a descriptive study conducted in two hospital centers in France to assess nurses internal contamination by antineoplastic drugs.
The increase of cancer incidence contributes to a growing number of administered
chemotherapies in care services. These antineoplastic drugs are not selective in their
mechanisms of action, affecting noncancerous as well as cancerous cells, leading to several
known side effects in treated patients. Health care professionals are increasingly exposed to
antineoplastic drugs and can be potentially contaminated by these molecules. This is a key
concern as part of assessment and occupational risk management in healthcare settings.
Occupational Health and Safety Department, in collaboration with Clinical and Toxicology
Laboratory of university Hospital Bordeaux, developed analytical tools to assess this
contamination in health care professional's urines, and the new acquisition of a
high-sensitivity measurement equipment (LC-MS/MS) improved assays methods in terms of
sensitivity and detection limits.
The main objective of the study is to assess internal contamination prevalence by the studied
antineoplastic drugs (5-fluorouracil, cyclophosphamide, doxorubicin, ifosfamide,
methotrexate) in nursing staff who administers these chemotherapies or is in charge of
patients treated by these chemotherapies, in two French hospital centers: University Hospital
Bordeaux and IUCT-Oncopole of Toulouse (Institut Universitaire du Cancer de Toulouse),
including about fifteen services selected on their use of these specific chemotherapies.
The secondary objectives of the study are on the one hand, to describe for each of the five
studied antineoplastic drugs the internal contamination prevalence in nursing staff, and
concentration level associated to this contamination in contaminated nursing staff, and on
the other hand, to identify contamination-associated factors in exposure characteristics and
personal protective equipment use.
This is a descriptive, multicentre, transverse and prospective study.
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