Clinical Trials Logo
  1. Home
  2. Anticoagulants; Increased
  3. NCT04891861

Restart TICrH Alpha Pilot Protocol, Restarting DOACs After Traumatic Intracranial Hemorrhage

Anticoagulants; Increased Clinical Trial

Official title:
A Pilot Trial of Restarting Direct Oral Anticoagulants After Traumatic Intracranial Hemorrhage

Clinical Trial Summary

Randomized pilot trial of restarting DOACs at 1 week versus 4 weeks after traumatic intracranial hemorrhage

Clinical Trial Description

Restart TICrH two-center pilot trial will assign patients with anticoagulant-associated traumatic intracranial hemorrhage to restart anticoagulation at 1 week or 4 weeks. Entry into the trial is primarily driven pragmatically by clinician intent to restart any Direct Oral Anticoagulant (DOAC, i.e. apixaban, rivaroxaban, edoxaban, dabigatran. There is no head to head evidence of superiority of any drug) after anticoagulant-associated traumatic intracranial hemorrhage and equipoise concerning restart of anticoagulation at the specified time intervals. DOAC will be at label dose with label adjustments for creatinine clearance. DOAC will be at continuation dose, i.e. not initial therapy high doses in the setting of VTE. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04891861
Study type Interventional
Source University of Texas at Austin
Contact Truman J Milling, MD
Phone 5124969742
Email tmilling@ascension.org
Status Not yet recruiting
Phase Phase 3
Start date July 1, 2021
Completion date July 1, 2023
View Details
See also
  Status Clinical Trial Phase
Completed NCT04719182 - Practice of Adjunctive Treatments in Intensive Care Unit Patients With COVID-19
Not yet recruiting NCT04849312 - Prediction of 30-Day Readmission Using Machine Learning
Active, not recruiting NCT04784351 - Prediction of Expected Length of Hospital Stay Using Machine Learning
Active, not recruiting NCT05045742 - Prediction of Patient Deterioration Using Machine Learning
Recruiting NCT03885180 - Randomized Evaluation of D-dimer Guiding dUration of Oral antiCoagulation thErapy N/A
Completed NCT03203759 - Hospital-Level Care at Home for Acutely Ill Adults N/A
Not yet recruiting NCT05705076 - Efficacy of Direct Oral Anticoagulants as a Prophylactic Anticoagulation of Catheter Induced Thrombosis N/A
Recruiting NCT03524222 - Home Hospital for Suddenly Ill Adults N/A
Completed NCT04531280 - Rural Home Hospital: Proof of Concept N/A
Recruiting NCT06341231 - Personalized Anticoagulant Therapy for Pulmonary Thromboembolism
Completed NCT03926780 - Comparative Study of Oral Anticoagulation in Left Ventricular Thrombi Phase 3
Completed NCT04080570 - Remote Physician Care for Home Hospital Patients N/A
Not yet recruiting NCT03217799 - Noninvasive Measurement of Blood Coagulation N/A