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Randomized Evaluation of D-dimer Guiding dUration of Oral antiCoagulation thErapy — REDUCE  

Valve Heart Disease Clinical Trial

Official title:
Randomized Evaluation of D-dimer Guiding Duration of Oral Anticoagulation Therapy in Patients With Bioprosthetic Heart Valves

Clinical Trial Summary

Guidelines recommended that patients with bioprosthetic heart valves (BHV) only need 6 months oral anticoagulation therapy after operation. However, a small part of patients still suffered thrombotic events after withdrawal of warfarin, which means these patients may need extend anticoagulation therapy. D-dimer, a sensitive marker of thrombosis or prethromboembolism state. Previous studies have demostrated that patients with elevated D-dimer levels have significant more clinical outcomes than those with nagative D-dimer levels. The aim of this study was to evaluate whether D-dimer could guide the duration of oral anticoagulation therapy in patients with BHV.

Clinical Trial Description

Patients with BHV were screened and enrolled in this study. D-dimer levels were measured in the sixth months after BHV operation but before withdrawal of warfarin. Patients with elevated D-dimer were randomized to extend anticoagulation therapy group and routine stopping anticoagulation group. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03885180
Study type Interventional
Source Wuhan Asia Heart Hospital
Contact
Status Recruiting
Phase N/A
Start date March 20, 2019
Completion date March 30, 2021
View Details
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