Post-surgical Aortic Hemodynamics After Aortic Valve Replacement

Status Completed

Clinical Trial Summary

The purpose of this pilot study is to obtain both near valve and downstream flow characteristics, using 3D transthoracic echocardiography and 4D flow MRI respectively, in an existing patient population at Northwestern Memorial Hospital, to determine the hinge washout characteristics and downstream flow patterns of the On-X valve and compared to competing designs.

Clinical Trial Description

Prospective, concurrent 4D flow Magnetic Resonance Imaging (MRI) and echocardiography of On-X and St Jude Medical (SJM) Masters HP or Carbomedics Carbo-seal or Carbo-seal Valsalva aortic valve replacement (AVR) patients will be performed. Echocardiography analysis will include: valve function (opening angle), pressure gradients, and degree of valve washout. MRI analysis will focus on downstream flow patterns (helicity and vorticity), energy loss, pressure recovery, and measurement of wall shear stress in the anastomosis regions. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03347851
Study type	Observational
Source	CryoLife, Inc.
Contact
Status	Completed
Phase
Start date	October 26, 2017
Completion date	June 1, 2020

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