Antibiotic Sore Tongue Clinical Trial
Official title:
Antibiotic Observatory for Respiratory Diseases, Apart From Tuberculosis and Reportable Diseases
the study aimed to determine the distribution of respiratory infections in Tunisian population and evaluate the frequency of antibiotics prescribed according to current international recommendations.
It is an observational, cross-sectional, multicenter, national clinical study . The study was
carried out from January 2018 to August 2018 in Tunisian population involving 57 primary care
outpatient centers and 6 emergency departments from the 24 departments of the country .
We included all patients with lower and upper respiratory tract infections (RTIs) who have
recieved antibiotic treatment.
Lower respiratory tract infection (LRTI) include pneumonia and acute bronchitis.
Acute upper respiratory tract infection (URTIs) include rhinitis, pharyngitis/tonsillitis,
and laryngitis. Rhinitis, also known as coryza, is irritation and inflammation of the mucous
membrane inside the nose.
The protocol of our study includes the demographic characteristics and the history of the
sample as well as the symptomatology at inclusion. The data from the clinical examination
were reported by the investigating doctor. After the diagnosis retained by the doctor is
noted with the management of the patient which includes additional explorations if they have
been requested. Finally, the investigating doctor specifies the antibiotic therapy
prescribed.Appropriateness of antibiotic prescription was assessed in patients managed in the
EDs . We used the MAI score (medication appropriateness index) wich includes 10 criteria. For
each criterion, the evaluator rates whether the medication is appropriate, marginally
appropriate, or inappropriate. Support is provided through explicit definitions and
instructions.The MAI has been used in observational and interventional studies.Its
feasibility, content validity, predictive validity, and reliability have been demonstrated in
ambulatory settings. The maximum score is 20 which translates into maximum inappropriateness.
If a patient is on multiple drugs, this test can be repeated for each drug in order to
determine a total MAI score.
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