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Usage of Procalcitonin to Reduce Antibiotics Duration in VAP in Neurosurgical ICU

Antibiotic Side Effect Clinical Trial

Official title:
Procalcitonin as a Sepsis Biomarker in Guiding Antibiotics Treatment Duration in Ventilator Associated Pneumonia in Neuro-ICU: A Randomised Controlled Trial

Clinical Trial Summary

Using Procalcitonin Tests to reduce antibiotics duration in Neurosurgical patients with Ventilated Associated Pneumonia

Clinical Trial Description

Patients who are more than 18 years old who are admitted to Neurosurgical ICU will be recruited 48hours after ventilation if matches criteria for ventilator associated pneumonia. Patients will be randomised into 2 groups. first group will be procalcitonin guided in addition to conventionally guided sepsis assessment (TWC, CRP, body temperature). second group is only conventionally guided sepsis assessment. in procalcitonin guided group, blood sample will be taken on Day 1 of recruitment and day 5. On day 5 , the procalcitonin level will be compared to recommendations in PRORATA trial. If procalcitonin level is below the level to withhold antibiotics, recommendation will be made to the primary physician to off the antibiotics. Another Procalcitonin level will be repeated on Day 7 to rule out reinfection. This study aims to compare the duration of antibiotics and length of ICU stay among the 2 groups. This study will fill up the gap among the lack of datas in neurosurgical patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06395454
Study type Interventional
Source Universiti Sains Malaysia
Contact Jerome Loh
Phone +60128589099
Email jeromederyang@hotmail.com
Status Not yet recruiting
Phase N/A
Start date July 1, 2024
Completion date June 30, 2025
View Details
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