Clinical Trials Logo
  1. Home
  2. Antibiotic Side Effect
  3. NCT06395454

Usage of Procalcitonin to Reduce Antibiotics Duration in VAP in Neurosurgical ICU

Antibiotic Side Effect Clinical Trial

Official title:
Procalcitonin as a Sepsis Biomarker in Guiding Antibiotics Treatment Duration in Ventilator Associated Pneumonia in Neuro-ICU: A Randomised Controlled Trial

Clinical Trial Summary

Using Procalcitonin Tests to reduce antibiotics duration in Neurosurgical patients with Ventilated Associated Pneumonia

Clinical Trial Description

Patients who are more than 18 years old who are admitted to Neurosurgical ICU will be recruited 48hours after ventilation if matches criteria for ventilator associated pneumonia. Patients will be randomised into 2 groups. first group will be procalcitonin guided in addition to conventionally guided sepsis assessment (TWC, CRP, body temperature). second group is only conventionally guided sepsis assessment. in procalcitonin guided group, blood sample will be taken on Day 1 of recruitment and day 5. On day 5 , the procalcitonin level will be compared to recommendations in PRORATA trial. If procalcitonin level is below the level to withhold antibiotics, recommendation will be made to the primary physician to off the antibiotics. Another Procalcitonin level will be repeated on Day 7 to rule out reinfection. This study aims to compare the duration of antibiotics and length of ICU stay among the 2 groups. This study will fill up the gap among the lack of datas in neurosurgical patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06395454
Study type Interventional
Source Universiti Sains Malaysia
Contact Jerome Loh
Phone +60128589099
Email jeromederyang@hotmail.com
Status Not yet recruiting
Phase N/A
Start date May 1, 2024
Completion date December 31, 2024
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT04081792 - Optimal Antibiotics for Operated Diabetic Foot Infections N/A
Recruiting NCT05499481 - Short Against Long Antibiotic Therapy for Infected Orthopedic Sites Phase 3
Recruiting NCT05950984 - Medical Device (MD) Derived Pharmacokinetic (PK) Parameters for Vancomycin (MD-PK)
Completed NCT03199911 - Topical Antibiotic Prophylaxis for Eyelids Phase 4
Completed NCT05355571 - The Impact of Probiotic Supplementation on Antibiotic Induced Changes in Gastrointestinal Function and/or Faecal Microbiota Composition N/A
Recruiting NCT05699174 - PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation Phase 3
Completed NCT03087890 - Impact of Cotrimoxazole Use in Immunocompetent HIV Patients on Carriage of Antimicrobial Resistant Bacteria Phase 4
Completed NCT01254097 - Probiotics in Primary Care N/A
Recruiting NCT06018792 - Molecular Culture for the Diagnosis of Pediatric Sepsis
Completed NCT06030713 - Timing of Maternal Antibiotic Prophylaxis During a Cesarean Section and the Early Infant Gut Microbiome N/A
Active, not recruiting NCT05027893 - Complications After Lower Third Molar Surgery N/A
Not yet recruiting NCT03935828 - Effect of Topical Sinonasal Antibiotics Phase 2
Not yet recruiting NCT06383637 - Antibiotic Use and Resistance KAP Among Dental Interns
Enrolling by invitation NCT04707092 - Use of Preoperative and Postoperative Antimicrobial Treatment Phase 4
Recruiting NCT03932708 - Improving Antibiotic Use in Urgent Care Facilities N/A
Recruiting NCT04731025 - Local Antibiotics for Breast Implants Phase 3
Completed NCT04403334 - Postoperative Safety Outcomes of Intraoperative Intracameral Preservative-Free Moxifloxacin Versus Levofloxacin Phase 4
Completed NCT04127682 - Antibiotic Prescription for Children With Acute Upper Respiratory Tract Infections in Assiut District
Completed NCT05742295 - Prevention of Cefoperazone-induced Coagulopathy Phase 4
Not yet recruiting NCT06250413 - Autoflor -Lyophilized Capsulated Autological FMT to Restore Gut Microbiome After Treatment With Antibiotics N/A