Antibiotic Resistant Infection Clinical Trial
Official title:
Patterns of Antibiotic Resistant Bacterial Infections in Liver Intensive Care Unit
the investigators want to identify the microbial profile, antibiotic resistant bacteria in hepatic patients with infections in Liver ICU, and explore risk factors and outcomes in those patients with antibiotic resistant bacteria.
Bacterial infection signifies major clinical challenge in cirrhotic patients where about 35%
of these patients acquire hospital-acquired infections compared with 5% of other hospital
in-patients without cirrhosis.It is associated with a mortality rate of 38% with a four-fold
increase compared to individuals without cirrhosis.
Cirrhotic patients have a high risk for antimicrobial resistance because of chronic use of
prescribed antibiotics like quinolones in secondary prophylaxis for spontaneous bacterial
peritonitis. In addition, undergoing invasive procedures and recurrent hospital admissions
encourage both increased occurrence of antimicrobial resistance and the spread of resistant
pathogens in these patients.
Epidemiology, risk factors and clinical outcomes of MDR infections have raised a special
attention in cirrhosis. Some studies reported bacterial resistance in about 50% of examined
patients and it is associated with treatment failure, septic shock and hospital mortality
especially in nosocomial and healthcare related infections
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