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CD64 and Antibiotics in Human Sepsis — CD64SEPLDX  

Sepsis Clinical Trial

Official title:
Monitoring CD64 on Neutrophils Regarding Effects of Antibiotics in Patients With SIRS Developing Sepsis

Clinical Trial Summary

The purpose of the study is to find out whether CD64 expression on neutrophils measured by a new bedside test (LeukoDx) within 30 minutes is associated with effective antibiotic therapy in critically ill adult patients at risk of sepsis.

Clinical Trial Description

In the present study, in critically ill patients with suspected infection undergoing application of antibiotics, CD64 and inflammatory plasma markers will be determined on days 1 to 4.

CD64 expression on the surface of neutrophils will be determined by fluorescence activated cell sorter (FACS) and with a new bedside test (LeukoDx).

The purpose of the study is to clarify:

1. Is CD64 expression on neutrophils associated with effective antibiotic therapy in critically ill adult patients at risk of sepsis?

2. Is CD64 expression associated with distinct plasma parameters of inflammation?

3. Do the results of the gold standard CD64 determination by FACS correlate with those of a new bedside test (LeukoDx)? ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02922998
Study type Observational
Source University of Ulm
Contact Manfred Weiss, MD
Phone 49 (0)731-500-60226
Email manfred.weiss@uni-ulm.de
Status Recruiting
Phase N/A
Start date September 2016
Completion date June 2019
View Details
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