Antibiotic-Associated Diarrhea Clinical Trial
Official title:
Comparison of Two Formulations of Lactobacillus Acidophilus and Lactobacillus Casei in the Prevention of Antibiotic-Associated Diarrhea: a Pilot Study
Main research Question: The investigators would like to find out if both the Bio-K
(lactobacillus acidophilus and lactobacillus casei) drink and capsule are equally effective
in the prevention of diarrhea associated with antibiotic use.
Why is this research project important? About 25% of patients who use antibiotics may
develop diarrhea as a side effect. Symptoms are mild and consist of watery diarrhea and
abdominal pain. Some patients may develop a more severe form of diarrhea, called clostridium
difficile-associated diarrhea. Clostridium difficile-associated diarrhea may lead to more
serious consequences like inflammation of the large bowel and in some cases, death. There
are some studies that suggest Bio-K drink, a probiotic preparation containing lactobacillus
acidophilus and lactobacillus casei, decreases the risk of diarrhea from antibiotic use. As
a result, St. Joseph's Healthcare has recently to use Bio-K routinely to try to reduce risk
of patients developing diarrhea. No other Hamilton hospitals use Bio-K routinely as there is
not strong evidence about the effectiveness of Bio-K for the prevention of diarrhea. This
study will provide more information about Bio-K's effectiveness in the prevention of
diarrhea associated with antibiotic use as both a capsule and a drink.
n/a
Allocation: Randomized, Endpoint Classification: Bio-equivalence Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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