Variations in Retinal Nerve Fiber Layer Thickness During Uncomplicated Anterior and Intermediate Uveitis

Anterior Uveitis Clinical Trial

Official title:

Variations in Retinal Nerve Fiber Layer Thickness During Uncomplicated Anterior and Intermediate Uveitis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02879084
• Other study ID #: 2017-3170
• Status: Completed
• Start date: August 2016
• Est. completion date: December 2020

Study information

• Verified date: January 2021
• Source: CHU de Quebec-Universite Laval
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study investigates the variations in the retinal nerve fiber layer (RNFL) thickness during uncomplicated anterior and intermediate uveitis, respectively. The objectives are to 1 ) confirm the RNFL thickening during an uncomplicated anterior uveitis as described in the literature, 2) measure the RNFL thickness during an uncomplicated intermediate uveitis specifically and 3) describe the variation in time of RNFL thickness during the two types of uveitis.

Description:

Thirty six individuals (18 with anterior uveitis and 18 with intermediate uveitis) will be recruited at the Centre universitaire d'ophtalmologie du CHU de Québec. RNFL thickness will be measured with optical coherence tomography at 3 times. For anterior uveitis, the RNFL thickness will be measured at presentation, 1 week and 4 to 6 weeks. For intermediate uveitis, the RNFL thickness will be measured at presentation, 4 to 6 weeks and 4 months. The initial thickness will be studied for each type of uveitis and progression over time will be studied also for each type of uveitis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 36
• Est. completion date: December 2020
• Est. primary completion date: December 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• 18 years old or more
• anterior uncomplicated uveitis or intermediate uncomplicated uveitis

Exclusion Criteria:

• history of uveitis in the past, other than the actual uveitis
• history of ophthalmologic pathology with potential impact on retinal nerve fiber layer thickness
• optic nerve or macular clinically apparent edema
• history of glaucoma or other optic neuropathy
• suspected or confirmed multiple sclerosis
• ocular hypertension (intraocular pressure more than 22 mmHg)
• reduced optical coherence tomography signal (lower than 7) on the Cirrus HD-OCT

Related Conditions & MeSH terms

• Anterior Uveitis
• Intermediate Uveitis
• Iridocyclitis
• Uveitis
• Uveitis, Anterior
• Uveitis, Intermediate

Locations

Country	Name	City	State
Canada	Centre universitaire d'ophtalmologie, Hôpital du Saint-Sacrement. CHU de Québec	Québec

Sponsors (1)

Lead Sponsor	Collaborator
CHU de Quebec-Universite Laval

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Retinal Nerve Fiber Layer Thickness in anterior uveitis		At time 0
Primary	Retinal Nerve Fiber Layer Thickness in intermediate uveitis		At time 0
Primary	Change from Baseline Retinal Nerve Fiber Layer Thickness in anterior uveitis		at 4 to 6 weeks
Primary	Change from Baseline Retinal Nerve Fiber Layer Thickness in intermediate uveitis		at 4 months