Anterior Uveitis Clinical Trial
Official title:
An Open Label Exploratory Study to Assess the Safety, Tolerability and Clinical Activity of Topically Applied ESBA105 in Patients With Acute Anterior Uveitis
The purpose of this study is to determine whether ESBA105, a topically applied TNF-alpha inhibitor, is safe and clinically active when applied to the eye of patients suffering from acute anterior uveitis
Acute anterior uveitis (AAU) is a common, recurrent disease characterized by inflammation of
the iris and ciliary body. Though usually effectively treated by topical corticosteroids,
novel treatment modalities are required to overcome the limitations and adverse effect
problems associated with the use of corticosteroids. TNF-alpha has been recognized as a
central disease mediator in AAU, as shown by preclinical models and clinical data with
systemically applied TNF-alpha inhibitors.
ESBA105 is a topically applied TNF-alpha inhibitor that is characterized by efficient
penetration into the eye resulting in high intraocular drug levels. A recently completed
Phase I trial confirmed that safety and tolerability of topical ESBA105 in healthy
individuals is excellent and systemic exposure is low.
In this pilot trial, the safety, local tolerability and clinical activity of topical ESBA105
in the treatment of patients with acute anterior uveitis shall be explored.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT00476593 -
Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications
|
N/A | |
Recruiting |
NCT01486693 -
Clinical Outcomes of Topical Ganciclovir Treatment in Cytomegalovirus Anterior Uveitis
|
N/A | |
Recruiting |
NCT01156285 -
Acute Anterior Uveitis: Psychic Burden and Pain
|
N/A | |
Terminated |
NCT00333996 -
A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Anterior Uveitis
|
Phase 2/Phase 3 | |
Completed |
NCT00405496 -
Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis
|
Phase 2 | |
Completed |
NCT02764697 -
Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients
|
Phase 4 | |
Completed |
NCT01376362 -
Topical Interferon Gamma for Macular Edema Secondary to Uveitis
|
Phase 1/Phase 2 | |
Recruiting |
NCT00407316 -
Quality of Life and Visual Function in Uveitis Patients
|
Phase 0 | |
Completed |
NCT02725177 -
Ocular Sarcoidosis Open Label Trial of ACTHAR Gel
|
N/A | |
Completed |
NCT01647529 -
Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / Endotheliitis
|
N/A | |
Completed |
NCT02517619 -
Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Non-Infectious Anterior Uveitis
|
Phase 3 | |
Completed |
NCT01505088 -
Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis
|
Phase 3 | |
Completed |
NCT02879084 -
Variations in Retinal Nerve Fiber Layer Thickness During Uncomplicated Anterior and Intermediate Uveitis
|
||
Completed |
NCT02765308 -
Aqueous Humor Dynamics and Hypertensive Uveitis
|
N/A | |
Completed |
NCT01154010 -
PEMF: an Adjunct Therapy for Anterior Uveitis
|
N/A | |
Completed |
NCT00130637 -
Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis
|
Phase 2 | |
Completed |
NCT00406887 -
Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis
|
Phase 3 | |
Completed |
NCT00876434 -
Subconjunctival Sirolimus for the Treatment of Autoimmune Active Anterior Uveiti
|
Phase 1 |