Effects of Pressure-controlled Intermittent Coronary Sinus Occlusion (PiCSO) Therapy on miRNAs Expression and Absolute Microvascular Resistance by Continuous Thermodilution in ST-segment Elevation Myocardial Infarction (STEMI) Patients: PiCSO-STEMI TRIAL — PiCSO-STEMI  

Anterior Myocardial Infarction Clinical Trial

Official title: Effects of Pressure-controlled Intermittent Coronary Sinus Occlusion (PiCSO) Therapy on miRNAs Expression and Absolute Microvascular Resistance by Continuous Thermodilution in ST-segment Elevation Myocardial Infarction (STEMI) Patients: PiCSO-STEMI TRIAL

Status Not yet recruiting

Clinical Trial Summary

In this study we pretend to determine the molecular (miRNAs expression, angiogenic and inflammatory biomarkers) and microcirculatory (assessed by the innovative continuous intracoronary thermodilution technique) effects of PiCSO compared to a standard PCI control group in patients with high-risk anterior STEMI. Then, we aim to assess the efficacy of these molecular biomarkers as prognostic tools. Also, we will evaluate the impact of PiCSO on the coronary microcirculation beyond the acute phase in the follow-up six months after STEMI. Finally, we will assess PiCSO influence on Heart Failure (HF) clinical variables and patients' quality of life including a cost-effectiveness assessment in the mid-term follow-up one year after the STEMI event.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Anterior Myocardial Infarction
• Anterior Wall Myocardial Infarction
• Infarction
• Myocardial Infarction
• ST Elevation Myocardial Infarction

• NCT number: NCT05644925
• Study type: Interventional
• Source: Fundacio Privada Mon Clinic Barcelona
• Status: Not yet recruiting
• Phase: N/A
• Start date: February 2024
• Completion date: February 2026