Ketone Supplementation in Eating Disorders

Anorexia Nervosa Clinical Trial

Official title: Starving for Energy - A Pilot Study to Test Ketone Derived Energy in Eating Disorders

Status Recruiting

Clinical Trial Summary

This study will investigate the effects of ketone supplementation on eating behavior including drive to binge eat or restrict, mood and anxiety in individuals with anorexia or bulimia nervosa. In addition, the investigators will contrast the effects of active ketone supplementation versus placebo on electroencephalogram (EEG) measurement. All subjects enrolled in the study will undergo EEG on two consecutive days at the beginning of the study, after active ketone supplementation or placebo drink, matched in taste to the ketone drink. Days will be randomized. Thereafter, all subjects will take the ketone supplementation drink for two weeks, twice daily.

Clinical Trial Description

The goals of the study are:

1) to test the effect of BHB as a nutritional supplement for AN and BN and 2) to test the ingestion of BHB on brain function.

Subjects will complete a battery of self-assessments and a diagnostic assessment in order to determine eligibility and for characterization of behavior to be used in later analyses. After eligibility is confirmed, subjects will complete 2 EEG scans on separate days after ingestion of Ketone supplement drink or placebo and will complete a taste reward task during the EEG scan. Subjects will then complete 2 weeks of daily ketone supplementation and self-assessments. ;

Related Conditions & MeSH terms

• Anorexia
• Anorexia Nervosa
• Atypical Anorexia Nervosa
• Bulimia
• Bulimia Nervosa
• Feeding and Eating Disorders

• NCT number: NCT05507008
• Study type: Interventional
• Source: University of California, San Diego
• Contact: Megan Shott, BS
• Phone: 858-246-5272
• Email: mshott@health.ucsd.edu
• Status: Recruiting
• Phase: N/A
• Start date: October 13, 2022
• Completion date: November 30, 2026