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Incentive Processing and Learning in Anorexia Nervosa and Bulimia Nervosa

Anorexia Nervosa Clinical Trial

Official title:
Incentive Processing and Learning in Anorexia Nervosa and Bulimia Nervosa

Clinical Trial Summary

The purpose of this study is to investigate areas of the brain responsible for 'liking', 'wanting', and learning in adults with eating disorders using brain imaging techniques, computer tasks, a test meal, and self-report questionnaires and interviews. The investigators will study changes in brain activity using a procedure called functional magnetic resonance imaging (fMRI). This study will include 252 women with an eating disorder (63 AN-restricting type (AN-R), 63 AN-binge eating/purging type (AN-BP), 63 bulimia nervosa (BN)) and 63 healthy controls (HC) aged 18-39. Aim 1: To examine neural differences in 'liking' and 'wanting' in ED relative to HC. Aim 2: To examine differences in instrumental learning for reward and punishment in ED relative to HC. Aim 3: To examine how 'liking' and 'wanting' drive instrumental learning in ED and predict clinical symptoms at baseline and 1 year later. Exploratory Aim: To explore the associations of dopamine function, as measured by neuromelanin MRI (NM-MRI), with ED diagnosis and brain response to 'liking', 'wanting', and learning.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05056597
Study type Observational
Source University of California, San Diego
Contact Christina Wierenga
Phone 858-534-8047
Email cwierenga@health.ucsd.edu
Status Recruiting
Phase
Start date May 26, 2022
Completion date January 2027
View Details
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