Adipokines and Ghrelin Concentrations in Different Stages of Anorexia Nervosa

Anorexia Nervosa Clinical Trial

Official title:

Adipocytokine and Ghrelin Concentrations in Different Stages of Anorexia Nervosa

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00602264
• Other study ID #: 503/5052006
• Secondary ID: 2005/1795
• Status: Completed
• Phase: N/A
• First received: January 15, 2008
• Last updated: January 25, 2008
• Start date: February 2006
• Est. completion date: May 2007

Study information

• Verified date: January 2008
• Source: Istanbul University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Turkey: Ethics Committee
• Study type: Observational

Clinical Trial Summary

The aim of this study is to determine serum concentrations of adiponectin (ApN), leptin and ghrelin in different stages of anorectic patients and to evaluate their relationships between biochemical, hormonal and anthropometric parameters.

Description:

Objective: The aim of this study is to determine serum concentrations of adiponectin (ApN), leptin and ghrelin in different stages of anorectic patients and to evaluate their relationships between biochemical, hormonal and anthropometric parameters.

Design: The study group is composed of four groups. Group1: Treatment-naïve patients with a recent diagnosis of AN (n:19), Group 2: The weight recovered (10 % increase in body weight compared with baseline weight) subgroup of group 1 at the end of a mean 117.72±98.14 days of follow-up (n: 12), Group 3: Recovered patients with a previous history of AN but normal menstrual cycles and body weight at the present time (n:10), Group 4: Control group: constitutionally thin healthy young women with normal menstrual cycles (n:10). Venous blood was obtained for measurements of biochemical parameters, ApN, leptin and ghrelin and body composition was determined by bioimpedance analysis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 41
• Est. completion date: May 2007
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 16 Years to 32 Years

Eligibility

Inclusion Criteria:

• Diagnosis of anorexia nervosa for Group 1-3

• Constitutionally thin healthy subjects for Group 4

Exclusion Criteria:

• Medical or psychiatric diagnosis other than anorexia nervosa,

• History of gastrointestinal disease for Group 1-3

• History of eating disorder or gastrointestinal or psychiatric disease for control group

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Adipokines
• Anorexia
• Anorexia Nervosa

Locations

Country	Name	City	State
Turkey	Istanbul Univetsity, Istanbul Medical Faculty, Department of Psychiatrics	Istanbul

Sponsors (1)

Lead Sponsor	Collaborator
Istanbul University

Country where clinical trial is conducted

Turkey,