Drug Transport in Patients With Anorexia Nervosa

Status Recruiting

Clinical Trial Summary

The aim of this study is to investigate whether patients with anorexia nervosa have elevated plasma cholesterol levels and, if elevated plasma cholesterol levels influence drug transport by the ABC-transporter P-gp (P-glycoprotein, MDR 1/ABCB1). We will isolate peripheral blood mononuclear cells (PBMCs) and total RNA from the blood of patients with anorexia nervosa and healthy subjects as control. PBMCs will be used for quantitative cholesterol determination and for measuring the activity of P-gp using a FACS (fluorescence-activated cell sorting) method (rhodamine123 efflux). Total RNA will be used for quantitative expression analysis of P-gp by reverse transcriptase real time PCR.

Clinical Trial Description

n/a

Study Design

Observational Model: Defined Population, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00176150
Study type	Observational
Source	Heidelberg University
Contact	Caroline Storch
Phone	0049 6221 56 39939
Email	caroline.storch@med.uni-heidelberg.de
Status	Recruiting
Phase	N/A

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