Secretin in Refeeding

Anorexia in Adolescence Clinical Trial

Official title:

Secretin Levels in Refeeding-induced Polyuria (Cross Section)

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05235867
• Other study ID #: IRB#21-001489
• Status: Recruiting
• Start date: February 1, 2022
• Est. completion date: December 31, 2024

Study information

• Verified date: March 2024
• Source: University of California, Los Angeles
• Contact: Misciel Macaraig
• Phone: 310-825-0922
• Email: mbmacaraig[@]mednet.ucla.edu
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Patients with restrictive-type anorexia nervosa who are admitted to the hospital for feeding often urinate excessive amounts. Others have changes in the way that they handle acid and base. These issues prolong hospitalizations. Current data suggest that one hormone--named secretin--may control both urine output and how the body handles acid and base. This study will evaluate whether secretin levels are different in anorexic patients who urinate an excessive amount compared to those who urinate normal amounts. For this study, patients will have one extra blood draw before and after one meal during their hospitalization. The blood draw before the meal coincides with a standard of care blood draw. Also after the meal, subjects will be asked to provide one extra urine sample. Information from subject's medical records will also be used.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 10
• Est. completion date: December 31, 2024
• Est. primary completion date: June 30, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 13 Years to 24 Years

Eligibility

Inclusion Criteria:

• Group 1:
• male and female patients
• age 13-24 years
• diagnosis of restrictive-type anorexia nervosa
• hospitalization for nutritional support
• >4 cc/kg/day of urine output (a.k.a. "fluid dumpers"; n=5)
• Group 2:
• male and female patients
• age 13-24 years
• diagnosis of restrictive-type anorexia nervosa
• hospitalization for nutritional support
• <2 cc/kg/d of urine output (a.k.a. "non-dumpers"; n=5)

Exclusion Criteria:

• 5150 hold
• Anti-depressant, anti-psychotic, or anticonvulsant medications
• Previous hospitalization within the past 6 months
• Underlying metabolic disorder not related to anorexia nervosa (including chronic kidney disease, renal tubular disorders, and underlying endocrine disorders)
• Pregnancy
• NG or G-tube feeds after day 2 of hospitalization
• > 10% of nutritional needs from supplemental feeds

Related Conditions & MeSH terms

• Anorexia
• Anorexia in Adolescence

Locations

Country	Name	City	State
United States	University of California, Los Angeles (UCLA)	Los Angeles	California

Sponsors (1)

Lead Sponsor	Collaborator
University of California, Los Angeles

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in secretin	Change in secretin value from pre- to post- meal	1 hour
Secondary	Change in serum bicarbonate	Change in bicarbonate value from pre- to post- meal	1 hour