Motive-specific Intervention for Negative Symptoms in Schizophrenia — MoNSS  

Anhedonia Clinical Trial

Official title: Treating Negative Symptoms of Schizophrenia With a Motive-specific Intervention: A Randomised Controlled Trial

Status Recruiting

Clinical Trial Summary

The aim of this study is to test a therapeutic intervention to reduce negative symptomatic among schizophrenia patients. Since the intervention can take place within an inpatient stay, it is a short intervention. Three appointments are made with the patients within two weeks. With an adaptation of the Autobiographical Memory Test (AMT) participants will be asked to recall events from the past and to imagine future events. Patients are additionally asked to complete tasks between the sessions. One pre- and one post-measurement of negative symptoms, motives, level of functioning, hope for recovery and other co-variables are part of the study. A follow-up appointment four weeks later is intended to provide information on the longer-term impact.

Clinical Trial Description

Clinically relevant negative symptoms are present in almost 60% of all patients suffering from schizophrenia. Motivational deficits seem to be one of the main barriers in the process of "functional recovery" among those patients and have been shown to be very treatment resistant. Effects of pharmacological compounds are at best moderate. There are some psychotherapeutic intervention studies that show promise but further controlled trials are needed to clarify the specific treatment effects.

Therefore, patients shall be encouraged to remember memories that stand in an association with specific motives. Motives are conscious and unconscious affect-based needs that are activated by behavior and influence behavior toward specific incentives in specific circumstances. They influence the selection of everyday goals and have influence on the degree of the progress people are making towards these goals. The intervention is based on the assumption that a positive expectation of the future is constituted among others by positive experiences from the past and at the same time increases the motivation for future behaviour. The activation of specific, motive-associated memories from autobiographical memory and their transformation into images of the future by means of imaginative methods could be a possible way of strengthening certain motives and thus increasing motivation for certain behaviour. This is mainly because there is evidence that psychosis patients have difficulties specifically remembering memories, i.e. those that happened on only one day. In addition, there is a diminished ability to create specific images of their personal future. ;

Related Conditions & MeSH terms

• Anhedonia
• Apathy
• Negative Type; Schizophrenic
• Schizophrenia

• NCT number: NCT04793438
• Study type: Interventional
• Source: University of Zurich
• Contact: Kleim Birgit, Prof. Dr.
• Phone: +41 44 384 21 11
• Email: birgit.kleim@pukzh.ch
• Status: Recruiting
• Phase: N/A
• Start date: January 1, 2021
• Completion date: June 30, 2022