Soft Tissue Sarcoma Clinical Trial
Official title:
A Non-Inferiority Study of Doxorubicin With Upfront Dexrazoxane for the Treatment of Advanced or Metastatic Soft Tissue Sarcoma
The purpose of this research study is to look at whether giving a drug called dexrazoxane with standard of care doxorubicin affects the progression of the disease. Dexrazoxane is often given at the same time as doxorubicin to help reduce the incidence and severity of disease of the heart muscle (which can be caused by doxorubicin). In January 2019 Eli Lilly and Company reported that the results of the Phase 3 study of olaratumab (Lartruvo), in combination with doxorubicin in patients with advanced or metastatic soft tissue sarcoma, did not confirm the clinical benefit of olaratumab in combination with doxorubicin as compared to doxorubicin alone. Therefore olaratumab is being removed from the front line standard of care regimen. Amendment #9 was made to the protocol to reflect these changes to the standard of care treatment.
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Status | Clinical Trial | Phase | |
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Recruiting |
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N/A | |
Recruiting |
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Phase 1 | |
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Phase 1 | |
Active, not recruiting |
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Phase 1/Phase 2 | |
Completed |
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Withdrawn |
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Phase 2 | |
Terminated |
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Phase 1 | |
Terminated |
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Phase 1 | |
Completed |
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Withdrawn |
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Ferumoxytol-Enhanced MRI in Adult/Pedi Sarcomas
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N/A | |
Completed |
NCT01440088 -
A Trial of TH-302 in Combination With Doxorubicin Versus Doxorubicin Alone to Treat Patients With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma
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Phase 3 | |
Completed |
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Amrubicin Chemotherapy as First Line in Metastatic or Unresectable Soft Tissue Sarcoma
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Phase 2 | |
Completed |
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Phase 1 | |
Recruiting |
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Phase 1/Phase 2 | |
Terminated |
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Phase 2 | |
Completed |
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Phase 1 | |
Completed |
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N/A | |
Completed |
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Recruiting |
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Terminated |
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Phase 3 |