Ischemic Stroke Clinical Trial
Official title:
Feasibility Study of Multiple Burrhole Therapy Combined With Intravenous Erythropoietin Pretreatment for Unstable Moyamoya
In this study, the investigators aim to evaluate the indirect revascularization outcomes of a new combination therapy of multiple burrhole procedure with promotion of arteriogenesis by intravenous (IV) erythropoietin (EPO) pretreatment on Moyamoya patients with acute neurological presentation, and outline the clinical and vascular factors associated with revascularization through the burrholes.
This is a investigator led, single-center, single arm, interventional trial in prospective
Moyamoya disease (MMD) and Moyamoya syndrome (MMS) registry. MMD or MMS patients with acute
neurological presentation such as ischemic stroke or transient ischemic attack are eligible.
After inclusion, initial evaluation including transfemoral angiography is performed. A 3 day
pre-procedure IV erythropoietin (120000 international units[IU] #3) is given for promotion
of arteriogenesis, than multiple burrhole procedure is performed. Arteriogenesis is
evaluated by 6 month transfemoral angiography.
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