Arteriovenous Malformations Clinical Trial
Official title:
Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms
The purpose of this pilot study is to investigate the use of minocycline and doxycycline as medical therapy for inoperable or partially treated arteriovenous malformations (AVMs) and giant aneurysms.
Arteriovenous malformations (AVMs) are a treatable cause of stroke in young adults. The
processes by which AVMs and giant aneurysms grow in size and spontaneously bleed are
unknown. The primary reason to treat AVMs and aneurysms is to guard against intracranial
bleeding.
This pilot study will examine the use of two common antibiotics—minocycline and
doxycycline—as medical therapy for inoperable or partially treated AVMs and giant aneurysms.
These drugs, which are tetracycline derivatives, can reduce the levels of a family of
enzymes, called matrix metalloproteases, that degrade tissue and thereby cause a reduction
in the risk of spontaneous bleeding from AVMs or aneurysm—which is the main cause of stroke
associated with these disorders. The enzymes can contribute to weaknesses in the wall of
blood vessels and may increase the risk of the vessel wall rupturing and causing spontaneous
bleeding.
This trial also will show that taking minocycline and doxycycline over an extended period in
this patient population is safe and well tolerated. Results from this study could help plan
future studies to benefit patients with abnormal blood vessels prone to bleeding in their
brains.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT03306836 -
Exploration of Anticoagulation Program in Cerebral Aneurysm and Arteriovenous Malformations With Hybrid Operation 2
|
N/A | |
| Recruiting |
NCT03306823 -
Exploration of Anticoagulation Program in Cerebral Aneurysm and Arteriovenous Malformations With Hybrid Operation 1
|
N/A | |
| Completed |
NCT01347307 -
Stereotactic Body Radiotherapy for Spine Tumors
|
N/A | |
| Recruiting |
NCT02042326 -
Prospective Evaluation of the Efficacy of Sirolimus (Rapamune®) in the Treatment of Severe Arteriovenous Malformations
|
Phase 2 | |
| Recruiting |
NCT05477680 -
Intraoperative Brain Shift Calculation Study
|
N/A | |
| Recruiting |
NCT05484245 -
Sonography-guided Resection of Brain Mass Lesions
|
N/A | |
| Recruiting |
NCT05484219 -
Functional Navigation in Surgery of Cerebral Tumors and Vascular Malformations
|
N/A | |
| Completed |
NCT03656211 -
Fertility After Diagnosis and Management of Acquired Uterine Arteriovenous Malformation
|
||
| Completed |
NCT04246125 -
Patient Skin Dose in Interventional Radiology
|
||
| Recruiting |
NCT02879071 -
Long Term Follow-up After Embolization of Brain Arteriovenous Malformations
|
||
| Terminated |
NCT01801488 -
Genome-wide Analysis of Single Nucleotide Polymorphisms of Brain Arteriovenous Malformations and Cerebral Aneurysm
|
N/A | |
| Recruiting |
NCT06259292 -
Comprehensive HHT Outcomes Registry of the United States (CHORUS)
|
||
| Recruiting |
NCT02098252 -
Treatment of Brain AVMs (TOBAS) Study
|
N/A | |
| Completed |
NCT02378883 -
Apollo™ Onyx™ Delivery Microcatheter Post Market Safety Study
|
N/A | |
| Completed |
NCT00783523 -
Influence of MMP on Brain AVM Hemorrhage
|
Phase 1 | |
| Recruiting |
NCT05276934 -
Brain Imaging After Non-traumatic Intracranial Hemorrhage (SAVEBRAINPWI)
|
||
| Recruiting |
NCT03031873 -
Evaluation of Susceptibility-weighted Magnetic Resonance Imaging and 4d-time-resolved Magnetic Resonance Angiography in Brain Arteriovenous Malformations
|
N/A | |
| Withdrawn |
NCT02079818 -
Visceral Artery Aneurysm Embolization by the Penumbra Ruby™ Coil System
|
Phase 4 | |
| Completed |
NCT01381952 -
Image Quality and Radiation Dose in Angiography
|
N/A | |
| Active, not recruiting |
NCT05418816 -
SelfWrap-Assisted Arteriovenous Fistulas
|
N/A |