Effect of Stellate Ganglion Block on Internal Mammary Artery Dynamics

Status Recruiting

Clinical Trial Summary

The aim of this study is to compare the diameter of Left internal mammary artery and its blood flow by using the pulsatility index before and after the left stellate ganglion block in patients undergoing coronary artery bypass grafting.

Clinical Trial Description

The internal mammary artery (IMA) is the preferred graft for myocardial revascularization because of its superiority over venous grafts owing to long term patency, lower mortality rates and improved post-operative outcomes. However, conduit spasm is a recognized complication of coronary artery bypass surgery mainly affecting the arterial conduits, a major concern that can lead to acute myocardial ischemia and may contribute to reduce graft patency. Topical application or systemic administration of many pharmacological agents has been shown to reverse or prevent graft spasm, but side effects are reported with the use of these agents. Various vasodilators that have been tried included various organic nitrates, calcium channel blockers, sodium nitroprusside (SNP) and papaverine. Over the last few years, there were some studies, which investigated the effect of regional anesthesia techniques such as thoracic epidural anesthesia (TEA) and stellate ganglion block (SGB) for sympatholysis and studied its effects on internal mammary artery diameter . The stellate ganglion block with local anesthetics have been widely used to provide pain relief to treat vascular spastic disorders of upper limbs, chronic pain conditions and treatment of refractory angina. The stellate ganglion block has also been used for increasing radial artery (RA) blood flow and preventing RA spasm by sympathetic blockade in coronary artery bypass surgery. In our study, two groups will be compared regarding the internal mammary artery diameter and its blood flow using the pulsatility index before and after stellate ganglion block. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05952011
Study type	Interventional
Source	Ain Shams University
Contact	Diaaeldin DA Aboelnile, MD, Lecturer
Phone	201018380033
Email	diaabadr@gmail.com
Status	Recruiting
Phase	Phase 4
Start date	August 8, 2023
Completion date	March 1, 2024

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