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Clinical Trial Summary

- To compare the effect (heart rate and mean arterial pressure) of Ringer Lactate preloading and without preloading on induction dose requirement of Propofol. - The Propofol requirement for induction dose with respect to loss of eyelash reflex in Ringer Lactate preloaded versus control group.


Clinical Trial Description

1. From the operation list, patients that meet the Inclusion criteria will be selected. (n=60) 2. Patients will be allocated into two participant groups. Group I and Group II respectively using Simple random sampling technique by Ballot method. Ballot method is to keep the list of patients that meet the inclusion criteria in two ballot box mentioning name and groups and do the lottery based selection for both groups and Patient code will be given. 3. Group I (n = 30) Preloading with Ringer Lactate 30 ml/kg over 30 mins prior to surgery will be done and Propofol dose (2mg / kg ) requirement for induction of anaesthesia will be noted. Group II (n = 30) No Preloading will be done and Propofol dose (2mg / kg) requirement for induction of anaesthesia will be noted. 4. Then, investigators will visualize for loss of eyelash reflex in both groups. 5. The hemodynamic response (heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure) to intubation between the two participant groups will be noted. The total Propofol requirement for induction in Ringer Lactate preloaded versus control group will be recorded. 6. Drug administration and parameters recording will be done by the anaesthesiologist / under supervision ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05777135
Study type Interventional
Source National Medical College Birgunj
Contact Dr Arushi Jaiswal
Phone +9779841675096
Email arushij.dr16@gmail.com
Status Recruiting
Phase Phase 4
Start date April 1, 2023
Completion date June 30, 2024

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