Orexin-A Levels in Insomnia Patients

Status Completed

Clinical Trial Summary

In the pathophysiology of insomnia, the increase of the orexin-A (OXA) peptide released from orexin neurons in the lateral hypothalamus plays an important role. Orexins takes part at the emergence of anesthesia. In the literature, investigators could not attain any studies about the arousal of insomnia patients from anesthesia. In this study, the effect of this peptide on the emergence process from anesthesia was investigated by comparing plasma OXA levels before and after anesthesia in insomnia patients.

Clinical Trial Description

ASA (American Society of Anesthesiologists) I-II patients aged 18-65 years who underwent elective laparoscopic cholecystectomy were included in the study. Patients were evaluated with the Jenkins Sleep Disorders scale and Epworth Sleepiness scale during preoperative examination and were divided into insomnia and control groups. Blood samples were obtained for OXA and glucose levels at anesthesia induction, 5 minutes after extubation and 30 minutes after extubation. The times from stopping anesthesia to eyes opening and extubation and end-tidal sevoflurane concentrations at these time points were recorded. ;

Study Design

Related Conditions & MeSH terms

Anesthesia
Insomnia
Sleep Initiation and Maintenance Disorders

Clinical Trial Details

NCT number	NCT05664295
Study type	Observational [Patient Registry]
Source	Mugla Sitki Koçman University
Contact
Status	Completed
Phase
Start date	December 30, 2022
Completion date	February 10, 2023

View Details

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