Effect of General Anesthesia Method on Cardiac Risk Patients on Ischemia Modified Markers

Anesthesia Clinical Trial

Official title:

Effect of General Anesthesia Method Chosen in Non-cardiac Surgery of Cardiac Risk Patients on Ischemia Modified Albumin and Heart-Type Fatty Acid-Binding Protein (H-FABP) Levels

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05662163
• Other study ID #: B.30.2.ATA.0.01.00/296
• Status: Not yet recruiting
• Phase: N/A
• Start date: December 30, 2022
• Est. completion date: December 30, 2023

Study information

• Verified date: December 2022
• Source: Ataturk University
• Contact: Aysenur Dostbil
• Phone: +905333677796
• Email: adostbil[@]hotmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To examine the effects of the general anesthesia method chosen in non-cardiac surgical operations of patients with cardiac risk on the levels of cardiac markers

Description:

To examine the effects of the general anesthesia method chosen in non-cardiac surgical operations of patients with cardiac risk on the levels of cardiac markers like; serum levels of the Creatine Kinase, Creatine Kinase Myocardial Band, high sensitive troponin, heart-type fatty acid-binding protein, ischemia-modified albumin and albumin. And evaluate the effect of anesthesia method on haemodynamic.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 70
• Est. completion date: December 30, 2023
• Est. primary completion date: June 30, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 85 Years

Eligibility

Inclusion Criteria:

• Being 18 years or older

• Getting a score of 2 and above according to the Lee cardiac index

• Having a non-cardiac surgical procedure that will take at least three hours

• ASA II or III

Exclusion Criteria:

• Under 18 years old

• Those who refused to participate in the study

• Patients with chronic renal failure

• Patients with creatinine value = 1.5 mg/dl

• Surgery that takes less than 3 hours

• Patients with liver failure

• Refusing to participate in the study

• Being allergic to the drugs used

Related Conditions & MeSH terms

• Anesthesia
• Ischemia

Intervention

Procedure:
• TIVA
Anesthesia will be maintained with propofol (6-10 mg/kg/hour) and remifentanil (0.1-0.3 µg/kg/min).
• GENERAL ANESTHESIA
Anesthesia will be maintained with sevoflurane (2 ml/min) 50% oxygen and remifentanil (0.1-0.3 µg/kg/min).

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Ataturk University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	comparing serum levels of ischemia modified albumin	serum levels of ischemia modified albumin (in terms of IU/ML)	intraoperative period
Primary	comparing serum levels of heart fatty acid binding protein	serum levels of heart fatty acid binding protein (in terms of mcg/L)	intraoperative period
Secondary	The effect of anesthesia method used in cardiac risk patients in terms of ephedrine consumption	used ephedrine amount (mg)	intraoperative period