Anesthesia Clinical Trial
Official title:
The Effects of Low Flow and Normal Flow Desflurane Anesthesia on Postoperative Liver and Renal Functions and Serum Cystatin C Levels in Geriatric Patients: A Prospective Randomized Controlled Study
NCT number | NCT05414721 |
Other study ID # | 2021/05-07 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | May 28, 2021 |
Est. completion date | March 30, 2022 |
Verified date | June 2022 |
Source | Yuzuncu Yil University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Aging is a physiological process. In the elderly, loss of functional reserve in all organ system, regression in anabolic processes and increase in catabolic processes are observed s (1). The number of geriatric patients is also increasing in our country. Technological developments in anesthesia and surgery technics show that we will provide medical services to more elderly patients over time(2). Cystatin C is excreted only by the kidney (7, 8). Serum cystatin C level is not affected by body muscle mass, age and gender. The half-life is short. Because of all these features, it is thought to be more sensitive than creatinine in evaluating kidney functions (8,9). In this study, it was aimed to compare the effects of low flow and normal flow desflurane anesthesia applied in geriatric patients on postoperative liver and kidney functions and serum cystatin C levels.
Status | Completed |
Enrollment | 60 |
Est. completion date | March 30, 2022 |
Est. primary completion date | January 28, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 65 Years to 100 Years |
Eligibility | Inclusion Criteria: - Patients with an American Society of Anesthesiologists (ASA) status of class I-III, - Aged between 65 and 100 years, - Scheduled to undergo general anesthesia and, the surgeries that will take longer than 1 hour. Exclusion Criteria: - ASA class = III patients - Thorasic surgery - Neurosurgery - Cardiorespiratory disease, - Uncontrolled diabetes mellitus, - Coagulation disorders, - Preoperative liver and renal dysfunction, - History of malignant hyperthermia, - Using nephrotoxic or hepatotoxic drugs, - Major bleeding (>1000 cc) is predicted in the operation, - Chronic alcoholism, - Patients with drug use or withdrawal symptoms |
Country | Name | City | State |
---|---|---|---|
Turkey | Van Yüzüncü Yil University, Faculty of Medicine | Van | Tusba |
Lead Sponsor | Collaborator |
---|---|
Yuzuncu Yil University |
Turkey,
Baum JA, Aitkenhead AR. Low-flow anaesthesia. Anaesthesia. 1995 Oct;50 Suppl:37-44. Review. — View Citation
Horwitz M, Jakobsson JG. Desflurane and sevoflurane use during low- and minimal-flow anesthesia at fixed vaporizer settings. Minerva Anestesiol. 2016 Feb;82(2):180-5. Epub 2015 Jul 22. — View Citation
Xie G, Jiang H. Clinical study of desflurane on low flow anesthesia compared with sevoflurane and enflurane. Chin Med J (Engl). 1997 Sep;110(9):707-10. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Alanin Aminotransferaz (ALT) | To research the serum alanin Aminotransferaz (ALT) , blood samples were taken pre-induction, post-surgery, and at the postoperative 24th hour by venous route. | 24 hours | |
Primary | Aspartat Aminotransferaz (AST) | To research the serum Aspartat Aminotransferaz (AST) , blood samples were taken pre-induction, post-surgery, and at the postoperative 24th hour by venous route. | 24 hours | |
Primary | Serum creatinine | To research the serum creatinine , blood samples were taken pre-induction, post-surgery, and at the postoperative 24th hour by venous route. | 24 hours | |
Primary | Serum cystatin C | To research the Serum cystatin C , blood samples were taken pre-induction, post-surgery, and at the postoperative 24th hour by venous route. | 24 hours | |
Primary | Blood urea nitrogen (BUN) | To research the Blood urea nitrogen (BUN) , blood samples were taken pre-induction, post-surgery, and at the postoperative 24th hour by venous route. | 24 hours | |
Secondary | Heart rate (HR) | HR were recorded before anesthesia induction and during surgery. | 6 hours | |
Secondary | Systolic blood pressure (SBP) | SBP were recorded before anesthesia induction and during surgery. | 6 hours | |
Secondary | Diastolic blood pressure (DBP) | DBP were recorded before anesthesia induction and during surgery. | 6 hours | |
Secondary | Mean blood pressure (MBP) | MBP were recorded before anesthesia induction and during surgery. | 6 hours | |
Secondary | Drug allergies | The patients were observed in terms of drug allergies, during the operation and in the postoperative period. | 24 hours | |
Secondary | Nausea-vomiting | The patients were observed in terms of nausea-vomiting during the operation and in the postoperative period. | 24 hours | |
Secondary | Shivering and agitation | The patients were observed in terms of shivering and agitation during the operation and in the postoperative period. | 24 hours | |
Secondary | Insufficient depth of anesthesia | The patients were monitored with BIS monitorization for complications such as nsufficient depth of anesthesia | During surgery |
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