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Clinical Trial Summary

This is a single centre, prospective feasibility study and pilot randomised controlled trial of patients scheduled for elective intermediate or major non-cardiac cancer surgery. The investigators plan to randomise up to 200 patients who meet the inclusion criteria to standard care or to personalised perioperative care based on pharmacogenomic testing for drugs commonly used in anaesthesia and postoperative pain management e.g., opioids - morphine, oxycodone and tramadol; anti-emetics - metoclopramide and ondansetron; and non-steroidal drugs - celecoxib and ibuprofen. The investigators hypothesise that pharmacogenomic testing is feasible prior to elective surgery and through 'personalised prescribing' for precision tailored perioperative care the investigators will improve patient's postoperative quality of recovery, including pain management.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT05063838
Study type Interventional
Source Peter MacCallum Cancer Centre, Australia
Contact Michelle D Gerstman, MBBS, MD
Phone +61 3 8559 7681
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date September 27, 2021
Completion date September 6, 2025

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