Clinical Trials Logo

Clinical Trial Summary

The arteriovenous fistula creation (AVF creation) surgery is essential among patients with end stage renal disease who require hemodialysis. The fistula usually locates at forearm, and is created by connecting artery and vein through surgery. Patients undergone hemodialysis through the fistula six weeks later if fistula becoming mature, which means patent vessel diameter and enough flow for hemodialysis. The primary failure rate of arteriovenous fistula creation is about 20% to 40% according to previous research data. Thrombosis is the most common cause of fistula failure, which require surgical intervention after arteriovenous fistula surgery. Anesthetic technique influences surgical outcome of arteriovenous fistula. General anesthesia, regional anesthesia, and local anesthesia are both wide-used methods. Regional anesthesia with nerve block remains the most popular method for arteriovenous fistula creation. The vessel dilation effect of regional anesthesia helps not only dilatation of artery and vein, but also the fistula itself, and promotes the successful functional dialysis. Various type of nerve block are used as anesthetic method for AVF creation surgery. People requiring hemodialysis usually have multiple underlying disease involving other major organ such as heart, lung, liver, and the endocrine system. They are more vulnerable to systemic intravenous anesthetic medication. The metabolic rate and pharmacodynamics of local anesthetic may also alter due to multiple systemic disease when compared with healthy adults. The optimal concentration of lidocaine for AVF creation when using axillary block has not yet been studied. This research is conducted for dosing response of different concentration of lidocaine when using axillary block for AVF creation surgery. We aim to investigate the optimal low effective concentration, the MEC90, which defined as 90% of patients can tolerate the operation at this concentration.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT05063578
Study type Interventional
Source Far Eastern Memorial Hospital
Status Recruiting
Phase N/A
Start date September 20, 2021
Completion date December 31, 2022

See also
  Status Clinical Trial Phase
Recruiting NCT04279054 - Decreased Neuraxial Morphine After Cesarean Delivery Early Phase 1
Active, not recruiting NCT04580030 - Tricuapid Annular Plane Sistolic Excursion Before General Anesthesia Can Predict Hypotension After Induction
Completed NCT03640442 - Modified Ramped Position for Intubation of Obese Females. N/A
Recruiting NCT04099693 - A Prospective Randomized Study of General Anesthesia Versus Anesthetist Administered Sedation for ERCP
Terminated NCT02481999 - Pre- and Postoperative EEG-Monitoring for Children Aged From 0,5 to 8 Years
Completed NCT04235894 - An Observer Rating Scale of Facial Expression Can Predict Dreaming in Propofol Anesthesia
Recruiting NCT05024084 - Desflurane and Sevoflurane Minimal Flow Anesthesia on Recovery and Anesthetic Depth Phase 4
Completed NCT04204785 - Noise in the OR at Induction: Patient and Anesthesiologists Perceptions N/A
Completed NCT03277872 - NoL, HR and MABP Responses to Tracheal Intubation Performed With MAC Blade Versus Glidescope N/A
Terminated NCT03940651 - Cardiac and Renal Biomarkers in Arthroplasty Surgery Phase 4
Completed NCT02529696 - Measuring Sedation in the Intensive Care Unit Using Wireless Accelerometers
Suspended NCT03704285 - Development of pk/pd Model of Propofol in Patients With Severe Burns
Recruiting NCT04567160 - NOL Index to Compare the Intraoperative Analgesic Effect of Propofol Versus Sevoflurane Phase 4
Completed NCT02894996 - Does the Response to a Mini-fluid Challenge of 3ml/kg in 2 Minutes Predict Fluid Responsiveness for Pediatric Patient? N/A
Not yet recruiting NCT05063838 - Perioperative Pharmacogenomic Testing N/A
Terminated NCT03567928 - Laryngeal Mask in Upper Gastrointestinal Procedures N/A
Completed NCT04163848 - CARbon Impact of aNesthesic Gas
Completed NCT04238741 - Audio-recording of Consent for Anaesthesia for Elective Caesarean Section N/A
Completed NCT03294213 - Prospective Non-interventional Evaluation of Intubation and Intensive Care Use of the New aScopeā„¢ 4 Broncho and aView
Not yet recruiting NCT03929315 - 3D OLV Training Intervention for Pediatric Anesthesia Trainees