Desflurane and Sevoflurane Minimal Flow Anesthesia on Recovery and Anesthetic Depth

Anesthesia Clinical Trial

Official title:

Comparison of Desflurane and Sevoflurane Minimal Flow Anesthesia on Recovery Parameters and Anesthetic Depth: a Randomized Prospective Study

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05024084
• Other study ID #: 2021-009
• Status: Recruiting
• Phase: Phase 4
• Start date: September 5, 2021
• Est. completion date: October 1, 2021

Study information

• Verified date: September 2021
• Source: Ufuk University
• Contact: Baturay K Kazbek, Ass. Prof.
• Phone: +903122044000
• Email: bkkazbek[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Minimal flow anesthesia has economic and environmental advantages in addition to providing earlier recovery following general anesthesia. There is a paucity of data concerning the effect of minimal flow anesthesia (fresh gas flow <0,5 l/min) on recovery parameters. The primary objective of this study is to compare the recovery parameters of desflurane and sevoflurane in minimal flow anesthesia while the secondary objective is to compare the effect of these agents on anesthetic depth using bispectral index.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 130
• Est. completion date: October 1, 2021
• Est. primary completion date: October 1, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Ages between 18 and 65
• Patients undergoing elective surgery under general anesthesia
• Patients with an American Society of Anesthesiologists Classification I or II

Exclusion Criteria:

• Patient refusal
• Emergency surgery
• Patients with a contraindication for minimal flow anesthesia
• Uncontrolled diabetes mellitus
• History of serious systemic disease (cardiac, pulmonary, hepatic)
• Utilization of another analgesic technique such as central or peripheral nerve blocks

Related Conditions & MeSH terms

• Anesthesia

Intervention

Procedure:
• Minimal flow anesthesia (fresh gas flow <0.5 l/min) using Sevoflurane
Sevoflurane will be used for the maintenance of general anesthesia which will be carried out using a fresh gas flow of less than 0,5 l/min
• Minimal flow anesthesia (fresh gas flow <0.5 l/min) using Desflurane
Desflurane will be used for the maintenance of general anesthesia which will be carried out using a fresh gas flow of less than 0,5 l/min

Locations

Country	Name	City	State
Turkey	Ufuk University Dr. Ridvan Ege Hospital	Ankara

Sponsors (1)

Lead Sponsor	Collaborator
Ufuk University

Country where clinical trial is conducted

Turkey, 

References & Publications (2)

Taskin D, Gedik E, Kayhan Z. Effects of Minimal Flow Sevoflurane or Desflurane Anaesthesia on Hemodynamic Parameters, Body Temperature and Anaesthetic Consumption. Turk J Anaesthesiol Reanim. 2020 Oct;48(5):356-363. doi: 10.5152/TJAR.2020.39699. Epub 2020 May 5. — View Citation

Werner JG, Castellon-Larios K, Thongrong C, Knudsen BE, Lowery DS, Antor MA, Bergese SD. Desflurane Allows for a Faster Emergence When Compared to Sevoflurane without Affecting the Baseline Cognitive Recovery Time. Front Med (Lausanne). 2015 Oct 28;2:75. doi: 10.3389/fmed.2015.00075. eCollection 2015. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Time until extubation	Time interval between discontinuation of the volatile anesthetics and removal of the endotracheal tube	Up to 10 minutes after discontinuation of the volatile anesthetic
Primary	Time until eye opening	Time interval between discontinuation of the volatile anesthetics and eye opening with verbal command	Up to 20 minutes after discontinuation of the volatile anesthetic
Primary	Time until transfer readiness	Time interval between discontinuation of the volatile anesthetics and Aldrete score reaching 9 or greater	Up to 45 minutes after discontinuation of the volatile anesthetic
Secondary	Anesthetic depth provided by the volatile anesthetic	Anesthetic depth as measured by Bispectral Index	Change in Bispectral Index values at 5, 10, 15, 30, 60 and 120 minutes