Diaphragm Functions in Bariatric Surgeries

Anesthesia Clinical Trial

Official title:

Evaluation of Diaphragm Functions in Laparoscopic Bariatric Surgeries

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04828408
• Other study ID #: 2019/02-16.derya
• Status: Completed
• Start date: March 1, 2019
• Est. completion date: September 2, 2019

Study information

• Verified date: March 2021
• Source: Turkiye Yuksek Ihtisas Education and Research Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Obesity is an important public health problem all over the world, and its prevalence is increasing every year. In obesity, significant changes occur in the mechanical properties of the lungs and chest wall due to fat deposits in the mediastinum and abdominal cavities. Upper abdominal surgical procedures usually cause impairment of respiratory functions by affecting respiratory volume and capacity. The risk of postoperative pulmonary complications increases with the decrease in restrictive capacities, hypoxemia, and increased respiratory work. It may also be due to causes such as diaphragm dysfunction, postoperative pain, and surgical incision.Ultrasonography (USG) is a method accepted for evaluating the normal and pathological conditions of the diaphragm. M-mode is used to evaluate the anatomical and functional disorders of the diaphragm. The diaphragm evaluation is performed with the anterior approach in the supine position and with different respiratory maneuvers (sniffing, deep inspiration, normal inspiration).

The aim of the study was to evaluate the diaphragm function by using USG and spirometry methods in patients who underwent bariatric surgery and to investigate the effect of postoperative pain score on diaphragm function.

Description:

Approval for this single-center, prospective, observational study was performed after the approval of the local Ethics Committee and informed consent from the patients.

Diaphragm ultrasonography was performed before general anesthesia, after general anesthesia in the recovery room, and at the postoperative 24th hour in normal breathing, deep inspiration, and sniffing position. For USG evaluation, while the patients sit in the supine position at an angle of 45⁰, the 2.5-7.5 Mhz convex probe is placed perpendicular to the intercostal spaces through the liver window on the anterior axillary line; The posterior part of the right hemidiaphragm was evaluated by directing it medially, cephalad and dorsally. Diaphragm movements in M-mode were evaluated after detection of the diaphragm in the B-mode. The inspiratory amplitude of the diaphragm (DIA: distance traveled by the diaphragm between the beginning and end of inspiration, cm) in M-mode, inspiratory velocity (IV= DIA/inspiratory time, cm/sec), and expiratory velocity (EV= DIA/expiratory time, cm/sec) measurements were made. VAS scores of the patients were questioned while performing USG.

Pulmonary function tests (PFT) of patients before surgery and the postoperative first day and FVC, FEV1, PEF, FEF25-75, and FEV1/FVC measurements have been recorded.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 45
• Est. completion date: September 2, 2019
• Est. primary completion date: September 1, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients with a body mass index (BMI) ?35,

• age interval of 18-65,

• ASA score II-III undergoing laparoscopic bariatric surgery

Exclusion Criteria:

• Patients with neuromuscular, cardiopulmonary, and cerebrovascular diseases,

• phrenic nerve damage or diaphragm paralysis,

• those who have undergone thoracic surgery,

• who could not communicate,

• who did not want to participate in the study,

• who used alcohol,

• those who needed postoperative intensive care,

• those who had surgical complications during surgery,

• those who were switched to open surgery

Related Conditions & MeSH terms

• Anesthesia
• Bariatric Surgery
• Diaphragm Disease
• Pulmonary Function Test
• Ultrasonography

Intervention

Procedure:
• Bariatric surgery
Patients with a body mass index (BMI) ?35, age interval of 18-65, and ASA score II-III undergoing laparoscopic bariatric surgery were included in the study. Patients with neuromuscular, cardiopulmonary, and cerebrovascular diseases, phrenic nerve damage or diaphragm paralysis, those who have undergone thoracic surgery, who could not communicate, who did not want to participate in the study, who used alcohol, those who needed postoperative intensive care, those who had surgical complications during surgery, and those who were switched to open surgery were not included in the study.

Locations

Country	Name	City	State
Turkey	University of Health Sciences Turkey, Bursa Yuksek Ihtisas Training and Research Hospital	Bursa	Yildirim

Sponsors (1)

Lead Sponsor	Collaborator
Turkiye Yuksek Ihtisas Education and Research Hospital

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	diaphragm function	change from baseline in diaphragm inspiratory amplitude at 24 hours	time from 10 minutes before anesthesia to 24 hours postoperatively