The Bern Perioperative Biobank

Anesthesia Clinical Trial

— BPBB  

Official title:

The Bern Perioperative Biobank to Define Perioperative Changes of Molecular Markers of Perioperative Organo-dysfunctions, Inflammation, Adverse Events and Disease Progression

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04767685
• Other study ID #: 041/09f
• Status: Completed
• Start date: January 2011
• Est. completion date: December 2021

Study information

• Verified date: November 2022
• Source: University Hospital Inselspital, Berne
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The goal of the research is to define clinically relevant molecular markers for increased risk of peri-/ postoperative organo-dysfunctions, inflammation, adverse events and disease progression. To better understand the perioperative impact the investigators aim to determine perioperative levels of molecular markers over time in the available samples and clinical data of the Bern perioperative Biobank (BPBB) cohort to finally increase quality of perioperative care of patients by permitting preventive measures to be taken early in patients at risk.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 547
• Est. completion date: December 2021
• Est. primary completion date: December 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• 18 years and older

• Written informed consent

• Non-emergency surgery

Exclusion Criteria

• Transient incapacity to consent or insufficient time (< 6h) to consider study participation

• No informed consent

• Cognitive impairment/Patients unable to consent

• Patients who retrospectively expressed their wish to be excluded

Related Conditions & MeSH terms

• Anesthesia
• Surgical Procedure, Operative

Locations

Country	Name	City	State
Switzerland	Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern	Bern

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital Inselspital, Berne

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Assessing the change of the metabolic profile in the perioperative setting	Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients' clinical outcome.	Before induction of anesthesia as baseline
Primary	Assessing the change of the metabolic profile in the perioperative setting	Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients' clinical outcome.	Ca. 2-5hours later upon finishing the surgery
Primary	Assessing the change of the metabolic profile in the perioperative setting	Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients' clinical outcome.	On postoperative day 1 during the morning round between 07:30-9:00am