Minimum Current for Train-of-four Monitoring

Anesthesia Clinical Trial

Official title:

Determination of the Minimum Current for Train-of-four Monitoring by Acceleromyography and Electromyography During the Recovery From General Anesthesia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04581720
• Other study ID #: 2020-06-017
• Status: Completed
• Phase: N/A
• Start date: October 12, 2020
• Est. completion date: July 6, 2021

Study information

• Verified date: July 2021
• Source: Ewha Womans University Mokdong Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Neuromuscular monitoring during general anesthesia is important to make sure adequate muscle relaxation during operation and adequate recovery of muscle power and spontaneous breathing during emergence from general anesthesia. The neuromuscular monitoring is usually using electrical stimulants and the method called train-of-four (TOF) is representative. Because it uses electrical stimulants, the patients could be uncomfortable and feel pain during the monitoring when the patients are conscious. Lowering the current of the stimulants would be helpful in reducing the pain, but there is a concern that the TOF results performed in lower current would be underestimated or inaccurate. Therefore, the investigators want to find the minimal current for TOF monitoring that shows adequate TOF results.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 36
• Est. completion date: July 6, 2021
• Est. primary completion date: July 6, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 65 Years

Eligibility

Inclusion Criteria:

• Age 20-65

• Scheduled for an elective surgery

• ASA physical status 1 or 2

Exclusion Criteria:

• BMI > 25 kg/m2

• Neuromuscular disease

• Decreased renal function

• Neurologic disorder

• Impossible to cooperate or communicate

Related Conditions & MeSH terms

• Anesthesia
• Anesthesia Recovery Period
• Neuromuscular Blockade

Intervention

Device:
• Train-of-four (TOF)
Give 4 electrical stimulants on the ulnar nerve to see if the 4 responses (T1 ~ T4) of adductor pollicis fade or not. If there's no neuromuscular block, it shows no fade, or it fades. When an operation is over under general anesthesia, we use the ratio of the height of T4 to T1, and the ratio is over 90%, the neuromuscular block is recovered enough to extubation.

Locations

Country	Name	City	State
Korea, Republic of	Ewha Womans University Mokdong Hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Ewha Womans University Mokdong Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Minimal current for TOF	The minimal current among the four currents we use which is showing not significantly lower TOF ratio than TOF ratio of supramaximal stimulant.	During the operation, from the height of T1 reaches back to the baseline, to the extubation of tracheal tube when the general anesthesia is over.