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NCT04327258 Clinical Trial

The Influence of NPPA/NPPB Haplotype on Natriuretic Peptide Plasma Levels

Anesthesia Clinical Trial

Official title:
The Influence of NPPA/NPPB Haplotype on Natriuretic Peptide Plasma Levels

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04327258
Other study ID # 041/09e
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 2011
Est. completion date December 2014

Study information
Verified date March 2020
Source University Hospital Inselspital, Berne
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Crosssectional study to analyse the genetic influence on levels of cardiac biomarkers (BNP, NT-proBNP).

Description:

Background

Natriuretic peptides play an important role in risk stratification and management of patients undergoing non-cardiac surgery. However, due to genetic variability, the levels of these biomarkers may differ in individual patients with cardiac derangement. In the preoperative setting, genetic contribution to natriuretic peptide plasma level variability has not yet been determined.

Objective

The aim of this study is to assess genetic contribution to NP plasma level variability in a Swiss cohort.

Methods

Cross-sectional association study in a cohort of non-cardiac surgery patients.

This study is a Subproject of a prospective cohort study registered under the ID 041/09.

Recruitment information / eligibility
Status Completed
Enrollment 437
Est. completion date December 2014
Est. primary completion date December 2014
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- 18 years and older

- Written informed consent

- Scheduled surgery

Exclusion Criteria

- No informed consent

- Cognitive impairment

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Switzerland Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern Bern

Sponsors (1)
Lead Sponsor Collaborator
University Hospital Inselspital, Berne

Country where clinical trial is conducted

Switzerland, 

Outcome
Type Measure Description Time frame Safety issue
Primary Influence of NPPA/NPPB haplotype on natriuretic peptide plasma levels Estimation of genetic effects on natriuretic peptide (BNP, NT-proBNP) plasma levels Blood samples collected at start of anesthetic procedure
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