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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT04112277
Other study ID # 2018-A03393-52
Secondary ID
Status Completed
Phase
First received
Last updated
Start date April 1, 2019
Est. completion date February 25, 2020

Study information

Verified date February 2020
Source Hôpital Privé Sévigné
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Opioid-free anesthesia (ATO) is a multimodal anaesthesia combining different analgesic and anesthetic modalities thus excluding opiates as an intraoperative. Recent studies have found a benefit from the ATO on postoperative rehabilitation and reduced length of hospitalization.

Periarticular infiltration with a local anesthetic is one of the measures proposed in OFA during the PTH.

PTH remains a painful procedure and the occurrence of morphinic-related side effects in sometimes elderly patients is often observed.

The main objective of this study is to assess the feasibility of ATO in anterior hip replacement under general anesthesia with the primary endpoint of morphine consumption measured 24 hours after surgery.


Recruitment information / eligibility

Status Completed
Enrollment 100
Est. completion date February 25, 2020
Est. primary completion date February 25, 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 85 Years
Eligibility Inclusion Criteria:

- Age 18 and 85

- ASA (American Society of Anesthesiology) I-III

- Total Hip Prosthesis programmed anteriorly

- Prior obtaining free and informed written consent .Affiliation or beneficiary of a social security scheme. Patients affiliated with or beneficiaries of a social security plan and not included in another trial.

Exclusion Criteria:

- Pregnant women or breastfeeding Spinal anesthesia Patient on long-term opiate Body Mass Index (BMI) - 20 or 45kg/m2 Incomprehension of the ENS scale Unaccompanied cardiac conduction disorder, Adam-Stokes syndrome Preoperative Spontaneous Cardiac Frequency - 40 beats/min Left ventricle ejection fraction - 40% Unpaired sleep apnea syndrome (OSA) Adult incompetent, adults under guardianship or curatorial or deprived of liberty Allergy to one of the protocol products or their excipients: levobupivacaine, paracetamol, pregabalin, ketoprofen, dexmedetomidine Paracetamol-specific contraindication: hepatocellular deficiency Ketoprofen-specific contraindications: creatinine clearance - 60ml/min, ATCD of perforated peptic ulcer, heart failure, progressive hemorrhage, asthma associated with ketoprofen use Contraindications to nefopam: symptomatic prostate disorders, angle-closing glaucoma, epilepsy Participation in another clinical study

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
Cumulative morphine consumption
morphine equivalent [mg] 24 hours after the procedure

Locations

Country Name City State
France Hopital Privé Sévigné Cesson-Sévigné

Sponsors (1)

Lead Sponsor Collaborator
Hôpital Privé Sévigné

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary Cumulative morphine consumption morphine equivalent [mg] 24 hours after the procedure
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