Dynamic Arterial Elastance During General Anesthesia Induction

Anesthesia Clinical Trial

Official title:

Dynamic Arterial Elastance as Predictive Parameter of Hypotension During General Anesthesia Induction.

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03910179
• Other study ID #: CLRIA-AC01
• Status: Recruiting
• Start date: September 10, 2019
• Est. completion date: April 2021

Study information

• Verified date: March 2020
• Source: Università Politecnica delle Marche
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study evaluates if dynamic arterial elastance measured before general anesthesia induction can predict the occurrence of hypotension due to general anesthesia induction.

Description:

As general anesthetics may be responsible for vasodilation and cardiac depression, arterial hypotension after induction of general anesthesia is a common event and may contribute to an adverse outcome. Dynamic arterial elastance has been proposed as a functional parameter of arterial tone and studies showed that it was able to predict pressure response to fluid administration in fluid-responsive patients and the amount of mean arterial pressure riduction as a conseguence of noradrenaline dose reduction in critically ill patients.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 65
• Est. completion date: April 2021
• Est. primary completion date: July 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients that will be undergone to general anesthesia for surgery

• Patients that need mini-invasive cardiac output monitoring during surgery

Exclusion Criteria:

• Age <18 yo

• Pregnancy

• Arrhythmia

• Severe valvular diseases

• Uncorrectable alterations of arterial signal

Related Conditions & MeSH terms

• Anesthesia

Locations

Country	Name	City	State
Italy	Azienda ospedaliero Universitaria Ospedali Riuniti Ancona	Ancona

Sponsors (1)

Lead Sponsor	Collaborator
Università Politecnica delle Marche

Country where clinical trial is conducted

Italy, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Baseline value of Eadyn as predictor of hypotension occurrence due to general anesthesia induction	Dynamic arterial elastance (Eadyn) will be recorded at baseline before induction of general anesthesia. Mean arterial pressure (MAP) will be recorded at baseline and continuously until tracheal intubation. The lowest value of MAP will be considered to define hypotension occurrence.	From baseline (before general anesthesia induction) up to 30 minutes.
Secondary	Correlation between Eadyn and severity of hypotension due to anesthesia induction	To evaluate the correlation between the baseline value of Eadyn and the severity of hypotension when it will occur after induction of general anesthesia	From baseline (before general anesthesia induction) up to 30 minutes.