Airway Management During TCI vs RSI Anesthesia Induction

Anesthesia Clinical Trial

Official title:

Airway Management and Safety Aspects During Target Controlled Infusion (TCI) Compared to Rapid Sequence Induction (RSI) of Anesthesia in Non-cardiac Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03723109
• Other study ID #: 2016/361-31 IV
• Status: Completed
• Start date: October 29, 2018
• Est. completion date: May 31, 2019

Study information

• Verified date: September 2019
• Source: Umeå University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aims of this observational study is to evaluate and compare feasibility of airway management during standardized TCI and RSI anesthesia induction.

Description:

The aims of this study are to evaluate and compare feasibility of airway management and risk for desaturation during standardized target controlled infusion (TCI) and rapid sequence induction (RSI) of anesthesia. A conventional way to induce anesthesia, i.e. manual injection of anesthetics, may be more accurate and predictable compared to dosing regimes based on complex mathematical algorithms used in TCI-systems. In addition, today many different models are presented and there is no consensus which kind of TCI-algorithm should be used universally. Moreover, dosing algorithms are most complex and challenging in underweight and morbid obesity. There are many publications on this field, but no data of feasibility of airway management can be found. Indeed, RSI induction is traditionally blamed to be risky and not recommended as a first choice.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 70
• Est. completion date: May 31, 2019
• Est. primary completion date: February 22, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• signed informed consent

• BMI < 35 kg/m2

• preoperative assessment accepted by consultant anesthesiologist

• scheduled for breast cancer surgery, endocrinological surgery (thyroid, parathyroid) or minor general abdominal surgery.

Exclusion Criteria:

• not signed consent

• instable angina pectoris

• severe bronchial asthma

• severe chronic obstructive pulmonary disease

• dementia

• severe heart valve disease

• severe renal failure

• body mass index > 35 kg/m2

Related Conditions & MeSH terms

• Adverse Effect
• Airway Complication of Anesthesia
• Anesthesia

Intervention

Procedure:
• Induction of anesthesia
Standardized TCI and RSI anesthesia induction

Locations

Country	Name	City	State
Sweden	Sunderby teaching hospital	Luleå

Sponsors (1)

Lead Sponsor	Collaborator
Umeå University

Country where clinical trial is conducted

Sweden, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Safety time for apnea	measurement of length of period for apnea during TCI and RSI induction by a timer	10min
Secondary	Duration of spontaneous breathing	measurement of duration of spontaneous breathing during TCI and RSI induction by a timer	10min