Assessment Of Carotid Flow During General Anesthesia

Anesthesia Clinical Trial

Official title:

Assessment of Fluid Responsiveness With Carotid Flow Change During General Anaesthesia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03713008
• Other study ID #: CART
• Status: Completed
• Phase: N/A
• Start date: October 22, 2018
• Est. completion date: March 30, 2019

Study information

• Verified date: October 2019
• Source: Medical University of Warsaw
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Proper identification of patients who would benefit from fluid infusion (fluid responsiveness) is one of the most crucial challenges in anaesthesia and critical care. Reliability of several invasive measurements used for this purpose for many years have been questioned recently. The study will evaluate consistency between carotid artery flow derivatives and standard haemodynamic measurement (LIDCO rapid) in navigation of intraoperative fluid therapy.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 61
• Est. completion date: March 30, 2019
• Est. primary completion date: March 30, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Major abdominal surgery

• Artery catheter required

Exclusion Criteria:

• Laparoscopic surgery

• Known history of carotid endarterectomy

• Known history of carotid stenosis

• Non-sinus rhythm

• Systolic or diastolic heart failure

• Chronic kidney disease

• Pulmonary hypertension

• Carotid artery anomaly

• Unable to visualise carotid artery

• Angle of correction > 60

Related Conditions & MeSH terms

• Anesthesia
• Fluid Responsiveness

Intervention

Diagnostic Test:
• Fluid bolus
All patients included in the study will receive 5 ml/kg fluid bolus of a balanced crystalloid solution.

Locations

Country	Name	City	State
Poland	Medical University Of Warsaw	Warsaw	Mazovian

Sponsors (1)

Lead Sponsor	Collaborator
Medical University of Warsaw

Country where clinical trial is conducted

Poland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in cardiac output	A measure of change of scaled cardiac output (nCO) with LiDCO device	Before and 2 minutes after intervention
Primary	Change in a corrected carotid artery flow	Ultrasound measure of corrected carotid artery flow time	Before and 2 minutes after intervention
Secondary	Change in pulse pressure variation	A measure of change of pulse pressure variation (PPV) with LiDCO device	Before and 2 minutes after intervention
Secondary	Change in stroke volume variation	A measure of change of pulse pressure variation with LiDCO device	Before and 2 minutes after intervention
Secondary	Change in a carotid blood flow	Ultrasound measure of corrected carotid blood flow time	Before and 2 minutes after intervention
Secondary	Change in a velocity time integral of carotid flow	Ultrasound measure of velocity time integral of carotid flow	Before and 2 minutes after intervention
Secondary	Change in the maximal systolic carotid velocity variation	Ultrasound measure of the maximal systolic carotid velocity variation	Before and 2 minutes after intervention